A Pharmacophore for Isatin-beta-Thiosemicarbazone Compounds with MDR1-Inverse Activity

One of the major hindrances to successful cancer chemotherapy is multi-drug resistance (MDR), which is frequently caused by the increased expression or activity of ABC transporter proteins. Research has generally been directed to overcoming MDR during cancer therapy by inhibiting the activity of ABC transporters. However, compounds that inhibit ABC transporter activity often elicit strong and undesirable side-effects, restricting their usefulness in therapy.   More...

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OTT Contributes a Book Chapter on Transfer and Valuation of Technology

OTT has contributed a chapter to Taxation and Valuation of Technology: Theory, Practice, and the Law, published by Irwin Law Inc. This chapter is entitled “Transfer and Valuation of Biomedical Intellectual Property.” By providing case studies and valuable informational resources, the chapter provides perspective on the interplay between government, academic, and commercial players necessary to bring products to the market.   More...  


Program Specialist Vacancy Announcement

The NIH Office of Technology Transfer is seeking a Program Specialist for the General Medicine Branch. This vacancy is being advertised under merit promotion procedures for status candidates under announcement HHS/NIH-2008-2570. The open period runs from Monday, June 30, 2008 - Tuesday, July 22, 2008.


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