Software Method for 2-D NMR Tissue Compartment Analysis

The invention pertains to a method for improving the accuracy of compartment characterization using NMR. Conventional methods use Laplace transformation analyzed one dimensional transverse NMR relaxometry to investigate spin-lattice decay of water in diverse body compartments using. This method, although used extensively, is inaccurate and limited by signal-to-noise obscurities and when the materials and compartments to be analyzed vary in size or have disparate relaxation characteristics.

The improved method of this invention utilizes the detection of a 2-dimensional (2-D) NMR signal, created through use of a standard pulse sequence and variations, analysis of the signal using inverse Laplace transform, followed by projection of the resultant 2-D data onto a single axis corresponding to the parameter of original interest. The method can be extended to analyses for 3-D or higher dimensional experiments and inverse Laplace transforms.

Potential Commercial Applications: Competitive Advantages:
  • Compartment analysis
  • Petroleum discovery
  • Multiple sclerosis
  • Compartment resolution

Development Stage:


Richard Spencer (NIA)  ➽ more inventions...

Hasan Celik (NIA)  ➽ more inventions...

Intellectual Property:
Software – Patent protection is not being pursued for this technology.

Licensing Contact:
Admin. Licensing Specialist (ALS),

OTT Reference No: E-734-2013/0
Updated: Oct 18, 2013