Peptides With Laminin Activity


Peptides with laminin activity, including YIGSR, are claimed. These peptides block angiogenesis, alter the formation of capillary structures by endothelial cells, prevent the formation of excess blood vessels in tissue and inhibit in vivo tumor cell colonization of tissues. These peptides can be used, among other things, to inhibit metastasis.

Potential Commercial Applications: Competitive Advantages:
  • cancer therapeutic
  • research reagent
 
  • encourage cell adhesion
  • inhibits metastasis and angiogenesis


Related Invention(s):
E-246-1988-0


Inventors:

Yoshihiko Yamada (NIDCR)  ➽ more inventions...

Makoto Sasaki (NIDCR)  ➽ more inventions...

Hynda Kleinman (NIDCR)  ➽ more inventions...

George Martin (NIDCR)  ➽ more inventions...

Jeannette Graf (NIDCR)  ➽ more inventions...

Yukihide Iwamoto ()  ➽ more inventions...

Frank Robey ()  ➽ more inventions...


Intellectual Property:
U.S. Pat: 5,092,885 issued 1992-03-03

Publications:
Y Iwamoto, M Nomizu, Y Yamada, Y Ito, K Tanaka, Y Sugioka. Inhibition of angiogenesis, tumor growth and experimental metastasis of human fibrosarcoma cell HT 1080 by a multimeric form of the laminin sequence Tyr-Ile-Ser-Arg (Y-I-G-S-R). B.J. Cancer 73:589, 1996.
WH Kim, HW Schnaper, M Nomizu, Y Yamada, HK Kleinman. Apoptosis in human fibrosarcoma cells is induced by a multimeric synthetic YIGSR-containing polypeptide from laminin. Cancer Res 54:5005, 1994.
K Yamamura, MC Kibbey, SH Jun, HK Kleinman. Effect of Matrigel and laminin peptide YIGSR on tumor growth and metastasis. Semin Cancer Biol 1993 Aug; 4(4):259-65.
M Nomizu, K Yamamura, HK Kleinman, Y Yamada. Multimeric forms of Tyr-Ile-Gly-Ser-Arg (YIGSR) peptide enhance the inhibition of tumor growth and metastasis. Cancer Res 1993 Aug 1;53(15):3459-61.
J Graf, Y Iwamoto, M Sasaki, GR Martin, HK Kleinman, FA Robey, Y Yamada. Identification of an amino acid sequence in laminin mediating cell attachment, chemotaxis, and receptor binding. Cell 1987 Mar 27;48(6):989-9.

Licensing Contact:
Vladimir Knezevic, M.D.
Email: vlado.knezevic@nih.gov
Phone: 301.443.5560

OTT Reference No: E-521-1986-3
Updated: Jun 15, 2010