Lepirudin Adsorbed to Catheter


The invention is a method for preventing venous access device (VAD) thrombosis by coating the VAD catheter with lepirudin, which has been found to be readily adsorbed by the silicone rubber of the VADs, and is expected to have good retention properties. VADs typically remain in place for weeks or months and sometimes cause clotting (thrombosis) of the veins. Accordingly, the simple technique of soaking a silicone catheter in lepirudin before venous insertion is the gist of the invention. Chronically ill patients who must be catheterized for long periods of time will benefit particularly from this technique which promises to reduce swelling and pain associated with VAD-induced thrombosis.

Inventors:

Mcdonald Horne (CC)  ➽ more inventions...


Intellectual Property:
US Application No. PCT/US03/40888

Publications:
MK Horne, KJ Brokaw, "Antithrombin activity of lepirudin adsorbed to silicone (polydimethylsiloxane) tubing," Thrombosis Research (2003) 112:111-115.

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OTT Reference No: E-295-2002/0
Updated: May 1, 2005