Topical Antibiotic for Faster Wound Healing


Currently available topical antibiotic formulations effectively eliminate bacteria at a wound site. Eliminating bacteria in the wound also eliminates the molecular signals present in bacterial DNA that stimulate the immune system's wound healing processes. Without these signals, the rate of wound healing is diminished.  

The present technology provides a means of improving the activity of topical antibiotics by supplementing the antibiotic formulation with immunostimulatory oligodeoxynucleotides (ODN).  These ODN express the CpG motifs present in bacterial DNA and safely mimic the immune stimulation induced by bacterial DNA.  The formulation may be applied directly to a wide variety of wounds to  skin (such as traumatic, burn, or surgical wound, or the eyes (such as corneal abrasions) to effectively eliminate infection and stimulate rapid healing of the wound.      



Potential Commercial Applications: Competitive Advantages:
  • Topical antibiotic
  • Wound healing for burn patients, patients with major surgeries and wounds.
 
  • Eliminates wound site bacteria while retaining immune stimulating properties
  • Promotes faster wound  healing


Development Stage:
Pre-clinical (in vivo)

Related Invention(s):
E-242-2007
756 filed


Inventors:

Dennis Klinman (NCI)  ➽ more inventions...


Intellectual Property:

Publications:
Ito H, et al. Antibiotics delay wound healing: an effect reversed by co-administering TLR7 and 9 ligands. Current Angiogenesis. 2012 Apr;1(1):46-51.
Sato T, et al. Accelerated wound healing mediated by activation of Toll-like receptor 9. PMID: 20946144
Yamamoto M, et al. The acceleration of wound healing in primates by the local administration of immunostimulatory CpG oligonucleotides. PMID: 21421264

Collaboration Opportunity:

Licensing and research collaboration


Licensing Contact:
John Hewes, Ph.D.
Email: John.Hewes@nih.gov
Phone: 240-276-5515

OTT Reference No: E-294-2011
Updated: Apr 23, 2018