Transformation of Weak or Non-Immunogenic Antigens to Produce an Immune Response and Therapeutic Polypeptides for the Treatment and Prevention of Cancer


A significant challenge in developing therapies for the treatment and prevention of cancer has been the discovery, selection, and exploitation of antigens.

Researchers at the National Institute on Aging (NIA) have partially circumvented this issue in their development of novel strategies for rendering weakly or non-immunogenic, shared antigens immunogenic, or able to produce an immune response.  These strategies use proinflammatory chemokines to deliver antigens to immature dendritic cells (DCs) by targeting chemokine receptors differentially expressed on antigen presenting cells (APCs).  Their work builds upon the discovery that tumor-associated, embryonic antigens (e.g., OFA-iLRP) – though non-antigenic alone – are effective for the treatment and/or prevention of cancer when linked to a chemoattractant ligand. Examples of such ligands include proinflammatory chemokines such as MIP3α/CCL20 or β-defensin mDF2β.  Multiple vaccines may be developed based upon individualized treatments for patients facing, or at risk of developing, the most aggressive forms of cancer.

The NIA is seeking statements of capability or interest from parties interested in licensing or collaborative research and development that can be applied to many cancer types. Such co-development opportunities would aim to further develop, evaluate, or commercialize simple and potent vaccines targeting embryonic and other antigens expressed in tumors.



Potential Commercial Applications: Competitive Advantages:
  • Treatment and prevention of solid tumors
  • Treatment and prevention of blood-borne tumors
 
  • Potential development of a prophylactic vaccine
  • Simple and less invasive approach; easily deliverable to the skin, muscle, and other tissues


Development Stage:
Pre-clinical (in vivo)

Inventors:

Arya Biragyn (NIA)  ➽ more inventions...

Dan Longo (NIA)  ➽ more inventions...

Igor Espinoza (NIA)  ➽ more inventions...


Intellectual Property:
U.S. Pat: 8,258,278 issued 2012-09-04

Publications:
Biragyn A, et al. Genetic fusion of chemokines to a self tumor antigen induces protective, T-cell dependent antitumor immunity   PMID 10096292
Schiavo, R, et al.  Chemokine receptor targeting efficiently cross presents antigens to MHC class I and elicit CD8+ T cell responses both in vitro and in vivo  PMID 1895803
Biragyn A, et al.  Tumor-associated embryonic antigen-expressing vaccines that target CCR6 elicit potent CD8+ T cell- mediated protective and therapeutic antitumor immunity  PMID 17617631

Collaboration Opportunity:

Licensing and research collaboration


Licensing Contact:
John Hewes, Ph.D.
Email: John.Hewes@nih.gov
Phone: 240-276-5515

OTT Reference No: E-271-2006
Updated: Aug 23, 2018