Knockout and Conditional Knockout Mice-GPR116


Pulmonary surfactant plays a critical role in preventing alveolar collapse by decreasing surface tension at the alveolar air-liquid interface. Surfactant deficiency contributes to the pathogenesis of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), common disorders that can afflict patients of all ages and carry a mortality rate greater than 25%. Excess surfactant leads to pulmonary alveolar proteinosis. NCI investigators created a G-protein coupled receptor GPR116 mutant mouse model and showed that GPR116 plays a previously unexpected, essential role in maintaining normal surfactant levels in the lung.

The mouse model could aid in the development of drug screens to identify agents that can modulate surfactant levels. Alveolar type II cells have also been isolated from the GPR116 wildtype and knockout mice that could be directly used in such assays. The identification of surfactant modulating agents could be important to a number of lung surfactant disorders.



Potential Commercial Applications: Competitive Advantages:
  • Useful as a research material to study lung surfactant homeostasis and disorders
 
  • This mutant mouse model is not available elsewhere


Development Stage:
Pre-clinical (in vivo)

Inventors:

Brad St. Croix (NCI)  ➽ more inventions...


Intellectual Property:

Publications:
Yang M, et al. Essential regulation of lung surfactant homeostasis by the orphan G protein-coupled receptor GPR116. PMID: 23684610

Collaboration Opportunity:

Licensing only


Licensing Contact:
John Hewes, Ph.D.
Email: John.Hewes@nih.gov
Phone: 240-276-5515

OTT Reference No: E-269-2012
Updated: Apr 23, 2018