Immunization for Ebola Virus Infection


The Ebola viruses, and the genetically related Marburg virus, are filoviruses associated with outbreaks of highly lethal hemorrhagic fever in humans and primates in North America, Europe and Africa. This invention relates to Ebola virus vaccines comprising nucleic acid molecules encoding Ebola viral proteins (including the transmembrane form of the viral Glycoprotein (GP), the secreted form of the viral Glycoprotein (sGP) and the viral nucleoprotein (NP)). The nucleic acid molecules of the vaccines of the invention encode structural gene products of any Ebola viral strain including the Zaire, Sudan, Ivory Coast and Reston strains as well as the genetically related Marburg virus strains. The invention relates to the nucleic acid vaccines as well as the corresponding protein vaccines. The invention also provides methods for immunizing a subject against disease caused by infection with Ebola virus.

Inventors:

Gary Nabel (NIAID)  ➽ more inventions...


Intellectual Property:
U.S. Pat: 6,852,324 issued 2005-02-08
US Application No. PCT/US98/27364
PCT Application No. 11/038,933

Licensing Contact:
Dianca Finch, Ph.D.
Email: dianca.finch@nih.gov
Phone: 240-669-5503

OTT Reference No: E-246-2001/0
Updated: May 1, 2002