T-Cell-Specific Gfi-1 Knockout Mouse


This is a mouse model available to study T-cell differentiation. Growth factor independent 1 (GFi-1) is a transcriptional repressor that is transiently induced during T-cell activation. This knockout mouse line is a GFi-1[flox/flox] introduced into a mouse Cre controlled by a CD4 promoter, which allows selective removal of GFi-1 exclusively in T-cells. It has thus-far been used to demonstrate that GFi-1 plays a critical role in enhancing Th2 cell expansion and repressing induction of Th17 and CD103+ iTreg cells.

Potential Commercial Applications: Competitive Advantages:
  • Tool for studying T-cell proliferation and differentiation.
 


Inventors:

Jinfang Zhu (NIAID)  ➽ more inventions...

William Paul (NIAID)  ➽ more inventions...


Intellectual Property:
Research Tool -- patent protection is not being pursued for this technology

Publications:
Zhu J, et al. PMID 19188499

Licensing Contact:
Yogikala Prabhu,
Email: prabhuyo@niaid.nih.gov
Phone: 301-761-7789

OTT Reference No: E-242-2009-0
Updated: May 16, 2018