Macromolecular Enzyme Substrates


This invention discloses a new class of reagents used to measure the activity of enzymes. The inventor discovered that connecting a small reagent molecule onto a polymer that serves as a large carrier molecule confers advantages in the measurement of enzyme activity. Advantages of the new class of reagents are: 1) better modeling of the size of natural targets (substrates) of many biologically important enzymes, 2) improved specificity of measurements, 3) ability to measure the influence of substrates size on enzyme activity (carrier group size can be varied over a wide range), 4) improved substrate solubility, and 5) the potential for easier methods of synthesis and purification of some enzyme substrates. Reagents of this class can be used to measure the activity of components forming and breaking down blood clots, of digestive components, of components of the complement system, and of many other components with essential biological functions.

Inventors:

Glen Hortin (CC)  ➽ more inventions...


Intellectual Property:
US Application No. 60/221,790
US Application No. PCT/US01/41496

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OTT Reference No: E-233-1999/0
Updated: Feb 1, 2001