Stabilized Group 2 Influenza Hemagglutinin Stem Region Trimers and Uses Thereof


Researchers at the Vaccine Research Center of the National Institute of Allergy and Infectious Diseases (NIAID) have designed influenza vaccine candidates based on group 2 influenza hemagglutinin (HA) proteins. These group 2 HA proteins were engineered to remove the highly variable head region and stabilize the remaining stem region. The researchers then fused the engineered group 2 HA stabilized stem with a ferritin subunit. The resulting fusion protein can self-assemble into nanoparticles which display group 2 HA stem domain trimers on their surface.

These immunogens elicit cross-reactive antibodies to group 2 influenza viruses and could be used in combination with group 1 HA stem-ferritin immunogens as a universal influenza vaccine. Interestingly, a recent study by Andrews et al., Sci. Immunol. 2, eaan2676 (2017), suggests that cross-reactive group 1/group 2 HA stem antibodies may be more likely to be elicited in humans by a group 2 HA immunogen.

This technology is available for licensing for commercial development in accordance with 35 U.S.C. § 209 and 37 CFR Part 404, as well as for further development and evaluation under a research collaboration.

Potential Commercial Applications: Competitive Advantages:
  • Use as a broadly protective influenza vaccine
 
  • Elicits antibodies to both group 1 and group 2 influenza A viruses
  • Nucleic acid or recombinant protein-based vaccine
  • Increased ease of production compared to current seasonal influenza vaccines


Related Invention(s):
E-293-2011-0


Inventors:

Masaru Kanekiyo (NIAID)  ➽ more inventions...

Jeffrey Boyington (NIAID)  ➽ more inventions...

Barney Graham (NIAID)  ➽ more inventions...

John Mascola (NIAID)  ➽ more inventions...

Hadi Yassine (NIAID)  ➽ more inventions...

Syed Moin (NIAID)  ➽ more inventions...

Lingshu Wang (NIAID)  ➽ more inventions...

Kizzmekia Corbett (NIAID)  ➽ more inventions...


Intellectual Property:
US Application No. 62/383,267
PCT Application No. PCT/US2017/049894
US Application No. 16/329,592

Licensing Contact:
Amy Petrik, Ph.D., J.D.
Email: amy.petrik@nih.gov
Phone: 240-627-3721

OTT Reference No: E-228-2016-0
Updated: Oct 17, 2018