Novel Radio-labeled Agents for Imaging Alzheimer's Disease-associated Amyloid

This technology introduces novel radio-labeled agents for imaging amyloid deposits in the brains of Alzheimer's Disease patients. These are small molecule, radio-ligand compounds that are analogs of benzo[d]thiazole. They are highly specific to amyloid, have low background noise, do not undergo rapid defluoridation and do not produce residual radioactivity in the brain. In addition, the compounds are stable and may be readily synthesized from commercially available starting materials. These compounds may be used in many noninvasive imaging techniques including: magnetic resonance spectroscopy (MRS) or imaging (MRI) or positron emission tomography (PET) or single-photon emission computed tomography (SPECT) to measure amyloid. Non-invasive detection of Alzheimer's disease-associated amyloid plaques in the brain would be valuable for early diagnosis, monitoring, and for clinical development of therapeutic drugs.

Potential Commercial Applications: Competitive Advantages:
  • Imaging agents for use in magnetic resonance spectroscopy (MRS), or imaging (MRI), positron emission tomography (PET) or single -photon emission computed tomography (SPECT).
  • Highly specificity to amyloid, low background, do not undergo rapid defluoridation and do not produce residual radioactivity in the brain.

Development Stage:

Related Invention(s):


Lisheng Cai (NIMH)  ➽ more inventions...

Victor Pike (NIMH)  ➽ more inventions...

Intellectual Property:
PCT Application No. PCT/US1255124
US Application No. 14/345,004
US Application No. 61/535,569

Cai L, et al. PMID 17722900
Cai L, et al. PMID 18078311

Collaboration Opportunity:

The National Institute of Mental Health (NIMH) is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize Beta-amyloid Imaging Agents. For collaboration opportunities, please contact Jennifer Wong at or 301-480-4821.

Licensing Contact:
Jennifer Wong, M.S.
Phone: 301-480-4821

OTT Reference No: E-225-2011/0
Updated: Aug 17, 2016