Respiratory Syncytial Virus Immunogens for Vaccine and Therapeutics Development


CDC researchers have developed specific Respiratory Syncytial Virus (RSV) immunogens for use in the development of RSV-directed vaccines and therapeutics. RSV is the most common cause of serious respiratory disease in infants and young children and an important cause of disease in the elderly. To date, efforts to make a mutually safe and effective vaccine have been largely unsuccessful. This invention addresses both problems.

CDC and collaborative researchers have demonstrated that a vaccine based on amino acid sequences corresponding to group-specific regions of the RSV G-protein can effectively induce antibodies, facilitate virus clearance, decrease the virus-induced inflammatory response to RSV challenge, and also decrease the enhanced disease following RSV challenge. This composition may be used alone as a vaccine to safely protect infants, children, and adults from RSV, as a booster with other RSV proteins or with inactivated virus as a vaccine to ensure that it can be given safely and effectively improve protection from RSV.



Potential Commercial Applications: Competitive Advantages:
  • Prophylactic and therapeutic for the prevention and treatment of RSV infections
  • Single or multi-component vaccine against RSV
  • Improvements to currently developed/developing vaccines
  • Developed antibodies may be employed for use in passive immunity or RSV research
 
  • Increased safety, effectiveness compared to current vaccines
  • Findings suggest likely prevention or mitigation of RSV-related pulmonary disease for previously established infections


Development Stage:
  • In vitro data available
  • In vivo data available (animal)


  • Related Invention(s):
    E-151-2013/0
    E-233-2013/0
    E-694-2013/0
    E-699-2013/0


    Inventors:

    Ralph Tripp (CDC)  ➽ more inventions...

    Larry Anderson (CDC)  ➽ more inventions...

    Lia Haynes (CDC)  ➽ more inventions...


    Intellectual Property:
    U.S. Pat: 8,771,706 issued 2014-07-08
    U.S. Pat: 8,846,056 issued 2014-09-30
    PCT Application No. PCT/US2010/044434
    US Application No. 13/388,839
    Several international patent applications pending

    Publications:
    Haynes LM, et al. PMID 19545210
    Miao C, et al. PMID 19264600

    Licensing Contact:
    Karen Surabian, J.D., M.B.A.
    Email: karen.surabian@nih.gov
    Phone: 301-594-9719

    OTT Reference No: E-197-2013/0
    Updated: Jan 16, 2014