Amino Acid Substitutions Mutants of Anthrax Protective Antigen, Lethal Factor, and Edema Factor


Anthrax toxin proteins available for licensing. Bacillus anthracis hosts containing plasmids expressing the following proteins are available. (Host strains are generally BH480, or sometimes BH460. Modest amounts of purified proteins (10-50 mg) could also be provided):
  1. PA. Protective antigen, wild type
  2. PA-3M (PA D683A, L685E, Y688K)
  3. PA-3M Cys
  4. PA-U7
  5. PA F427A
  6. PA K563C
  7. PA L687A
  8. PA-U7 K562C
  9. PA D512K
  10. PA GN
  11. PA-3M SoSi-H6
  12. FP59-AGG
  13. EF-A K313R
  14. LFn-linker-Cys
  15. LF E687A
  16. LFnBLA
  17. LFnFLA


Potential Commercial Applications: Competitive Advantages:
  • A research material that can be used in the development of assays, validation of products or in quality control.
 
  • Speed up product development with NIH developed material that has already been tested and validated.


Inventors:

Stephen Leppla (NIAID)  ➽ more inventions...


Intellectual Property:
Research Material – Patent protection is not being pursued for this technology. (IC Reference No. 2014-019)

Licensing Contact:
Wade Green,
Email: wade.green@nih.gov
Phone: 301-761-7505

OTT Reference No: E-196-2014-0
Updated: Jun 7, 2018