Inhibitors of Formation of Protease Resistant Prion Protein


Protease-resistant prion proteins are actively associated with various transmissible spongiform encephalopathies (TSEs). These include Creutzfeldt-Jakob disease (CJD) in humans and bovine spongiform encephalopathy (BSE) ("mad cow disease") in cattle.

The present invention discloses proprietary peptides and potential pharmaceutical compositions using such peptides that inhibit the formation of protease-resistant prion protein aggregates. These aggregates develop into amyloid deposits in the brain of affected patients, leading to the development of the spongiform encephalopathy. The peptides, when used in vitro inhibit such aggregation. Furthermore, when used in pharmaceutical compositions and medically relevant dosages, may be used for therapies for TSEs.

Inventors:

Bruce Chesebro (NIAID)  ➽ more inventions...

Byron Caughey (NIAID)  ➽ more inventions...

Joelle Chabry (NIAID)  ➽ more inventions...

Susette Priola ()  ➽ more inventions...


Intellectual Property:
U.S. Pat: 6,211,149 issued 2001-04-03
U.S. Pat: 6,355,610 issued 2002-03-12
US Application No. 10/096,080

Licensing Contact:
Jeffrey Thruston,
Email: jeffrey.thruston@nih.gov
Phone: 301-594-5179

OTT Reference No: E-189-1998-0
Updated: May 7, 2018