Pigment Epithelium Derived Factor: Characterization, Genomic Organization and Sequence of PEDF Gene

Retinal pigment epithelium (RPE) cells secrete a unique 50 kD protein. This protein, pigment epithelium-derived factor (PEDF), contains trophic activity in both the induction of neuronal cell differentiation as well as the survival of the mature neuron. This invention provides the complete genomic sequence of PEDF. It also discloses a truncated version of PEDF referred to as rPEDF, equivalent proteins, vectors comprising the nucleic acids, host cells into which the vectors have been introduced as well as a recombinant method for producing PEDF.

Potential Commercial Applications: Competitive Advantages:
  • research reagent
  • pharmaceutical composition
  • recombinant method
  • production of large quantities

Related Invention(s):



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Intellectual Property:
U.S. Pat: 7,179,621 issued 2007-02-20
U.S. Pat: 6,319,687 issued 2001-11-20
US Application No. 11/201,443
PCT Application No. PCT/US95/07201

Steele FR, et al. PMID 8434014
Becerra SP, et al. PMID 8226833

Licensing Contact:
Lynne Huang, Ph.D.
Email: yingling.huang@nih.gov
Phone: 240-276-5530

OTT Reference No: E-185-1992-3
Updated: May 10, 2018