Pigment Epithelium Derived Factor: Characterization of Its Novel Biological Activity and Sequences Encoding and Expressing the Protein

Pigment epithelium-derived factor (PEDF), a unique 50 kD protein secreted by retinal pigment epithelium (RPE) cells, has trophic activity. This invention describes the biological activity of PEDF, a method of enhancing neuron cell survival and a method of inhibiting glial cell proliferation, as well as purified antibodies to PEDF and an immunoassay. This technology can be used to develop therapeutics for the treatment of inflammatory, vascular, degenerative, and dystrophic diseases of the retina and central nervous system (CNS).

Potential Commercial Applications: Competitive Advantages:
  • Alzheimer's disease
  • Huntington's disease
  • Glutamate poisoning
  • Parkinson's disease
  • Enhance neuronal cell survival
  • Inhibit glial cell proliferation

Related Invention(s):


Gerald Chader (NEI)  ➽ more inventions...

Takayuki Taniwaki (NINDS)  ➽ more inventions...

Yukihiro Sugita (NINDS)  ➽ more inventions...

Intellectual Property:
U.S. Pat: 5,840,686 issued 1998-11-24
PCT Application No. PCT/US95/07201

Taniwaki T, et al. PMID 7760030

Licensing Contact:
Lynne Huang, Ph.D.
Email: yingling.huang@nih.gov
Phone: 240-276-5530

OTT Reference No: E-185-1992-1
Updated: May 14, 2018