Heterocyclic Compounds for the Treatment of Hepatitis C Virus


The vast majority of people infected with Hepatitis C Virus (HCV) will have chronic infection. Over decades, this can lead to liver disease and liver cancer. In fact, HCV infection is the leading cause of liver transplants in the U.S. Several new drugs have recently come into the market that have changed the HCV treatment paradigm. However, the effectiveness of these new drugs can vary depending on the HCV genotype. Furthermore, all oral, interferon free therapeutic regimens for HCV infection will need combinations of drugs that target different aspects of the HCV life cycle. Thus, there is still the need for additional new therapeutics against HCV.

The subject technologies are aryloxazole based small molecules that are potent inhibitors of HCV infection and replication. The compounds exhibit synergy with currently available therapeutics for HCV and represent a new class of anti-HCV compounds. The compounds affect the entry step of HCV infection, a step not targeted by currently available therapeutics against HCV.

Potential Commercial Applications: Competitive Advantages:
  • Prevention and treatment of HCV infection.
 
  • Potent inhibitors of HCV infection and replication.
  • Show synergistic effect with currently available HCV therapeutics.
  • Represent new class of HCV inhibitors that target the entry step of HCV infection.


Development Stage:
  • Early-stage
  • In vitro data available


Inventors:

Tsanyang (Jake) Liang (NIDDK)  ➽ more inventions...

Zongyi Hu (NIDDK)  ➽ more inventions...

Juan Marugan (NCATS)  ➽ more inventions...

Noel Southall (NCATS)  ➽ more inventions...

Xin Hu (NCATS)  ➽ more inventions...

Jingbo Xiao (NCATS)  ➽ more inventions...

Shanshan (Melissa) He (NIDDK)  ➽ more inventions...

Marc Ferrer-Alegre (NCATS)  ➽ more inventions...

Wei Zheng (NCATS)  ➽ more inventions...

Kevin Frankowski

Frank Schoenen

Kelin Li


Intellectual Property:
US Application No. 15/317,864
EP Application No. 15730666.3

Licensing Contact:
Carolyn Buller,
Email: carolyn.buller@nih.gov
Phone: 301-443-5605

OTT Reference No: E-161-2014-0
Updated: Aug 24, 2018