Methods For Inactivating Enveloped RNA Virus Particles And Compositions For Use Therewith


The inventors have discovered that treatment of enveloped single-stranded RNA viruses with eosinophil-derived neurotoxin (EDN), a ribonuclease, inactivates the viruses in cell culture. Respiratory Syncytial Virus (RSV) and Parainfluenza Virus (PIV) are medically the most important enveloped RNA viruses; together they hospitalize over 100,000 infants per year in the US. EDN is the major eosinophil ribonuclease. It has been cloned and recombinant EDN is available. Despite its name, EDN is not toxic to respiratory epithelial or other somatic cells. Both parenteral and aerosol administration are contemplated. Claimed are methods of treatment and pharmaceutical compositions.

Inventors:

Helene Rosenberg (NIAID)  ➽ more inventions...

Joseph Domachowske (NIAID)  ➽ more inventions...


Intellectual Property:
U.S. Pat: 6,426,070 issued 2002-07-30
US Application No. 60/052,986
PCT Application No. PCT/US98/13852

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OTT Reference No: E-161-1997/0
Updated: Jun 1, 1999