Metallic Nanoparticles for Photothermal Therapy


The invention relates to the preparation and application of 20-150nm metallic nanoparticulate vesicles for photothermal anti-cancer therapy. The vesicles comprise metallic nanoparticles covalently bound to a hydrophilic and hydrophobic polymer. The preparation method generally entails dispersing a polymer-bound metallic nanoparticle in an organic solvent, adding an aqueous solution with a dispersing aid, sonicating the mixture, and finally removing the organic solvent until the vesicle forms. The final vesicle is stable wherein the metallic nanoparticle is covalently bound to the hydrophobic and hydrophilic polymer. By way of a non-limiting example, an exemplary vesicles can be one made from gold nanorods coated with polyethylene glycol and polylactic-co-glycolic acid (AuNR@PEG/PLGA) in an oil-in-water emulsion.

Potential Commercial Applications: Competitive Advantages:
  • Cancer therapy
  • Tumor therapy
 
  • Prolonged circulation
  • High tumor accumulation
  • Rapid excretion
  • Enhanced photoacoustic signal
  • Enhanced photothermal effect/cancer therapy efficacy


Development Stage:
In vitro data available

Inventors:

Xiaoyuan (Shawn) Chen (NIBIB)  ➽ more inventions...

Jibin Song (NIBIB)  ➽ more inventions...


Intellectual Property:
US Application No. 62/266,289
PCT Application No. PCT/US2016/065708
US Application No. 15/781,940

Collaboration Opportunity:

The National Institute of Biomedical Imaging and Bioengineering seeks statements of capability or interest from parties interested in collaborative research to further develop and evaluate metallic nanoparticle vesicles for cancer phototherapy. For collaboration opportunities, please contact Cecilia Pazman, Ph.D. at pazmance@nhlbi.nih.gov.


Licensing Contact:
Michael Shmilovich, J.D.
Email: shmilovm@mail.nih.gov
Phone: 301-435-5019

OTT Reference No: E-158-2015-0
Updated: Jan 4, 2016