Computer Controlled Aerosol Generator with Multi-Walled Carbon Nanotube Inhalation Testing Capabilities


This invention pertains to a CDC developed sonic aerosol generator that provides a controllable, stable concentration of particulate aerosol over a long period of time for aerosol exposure studies. Specifically, in situ testing data indicate uniform aerosol stability can be maintainable for greater than 30 hours at concentrations of 15 mg/m3 or more. Additionally, the technology was specifically developed for, and validated in, animal studies assessing exposure to airborne multi-walled carbon nanotubes (MWCNT). It has been suggested that workers may be at risk for exposure to nanosized particles during the manufacture, handling, and cleanup of engineered nanomaterials. Compared to other technologies, this CDC aerosol generator is particularly helpful when used for generating high testing concentrations of MWCNT aerosols that more accurately represent particulate levels that may be seen in a workplace environment.

Potential Commercial Applications: Competitive Advantages:
  • Studying the size and shape of the aerosolized particles produced from simple vibrations of bulk material
  • Toxicological investigations and risk assessment of aerosol exposures, especially those related to nanoparticle manufacturing
  • Any aerosolization application where the aggregating “bird's nest” tendencies of airborne multi-walled carbon nanotubes must be overcome
 
  • Fully automated system with integrated feedback control for optimized stability in testing
  • Maintains concentration of aerosols for >30 hours at concentrations of 15 mg/cubic meter or more
  • Capable of generating high concentrations of aerosols that more accurately represent the levels seen in a workplace environment
  • System insures that each run produces a constant particle concentration, air flow, pressure, temperature and humidity within a testing chamber


Development Stage:
  • In vitro data available
  • In vivo data available (animal)
  • In situ data available (on-site)
  • Prototype


Inventors:

Walter McKinney (CDC)  ➽ more inventions...

David Frazer (CDC)  ➽ more inventions...

Bean Chen (CDC)  ➽ more inventions...


Intellectual Property:
U.S. Pat: 8,875,702 issued 2014-11-04
US Application No. 12/871,453
US Application No. 14/473,324

Publications:
McKinney W, et al. PMID 19555230
Porter DW, et al. PMID 22881873
Porter DW, et al. PMID 19857541
Chen BT, et al. PMID 23033994

Licensing Contact:
Karen Surabian, J.D., M.B.A.
Email: karen.surabian@nih.gov
Phone: 301-594-9719

OTT Reference No: E-156-2013/0
Updated: Mar 17, 2014