Monoclonal Antibodies to the HIV-1 Core Protein p24


The core proteins of HIV-1 are secreted into the environment during replication in the human body. The detection of the core protein p24 (molecular mass of 24 kilodaltons) serves as an indicator of early HIV-1 infection, and assays detecting it have been available since the late 1980s. However, the development of a rapid assay for the detection of HIV-1 p24 has only recently become available. Monoclonal antibodies developed in our laboratory for research and development of a rapid HIV-1 p24 assay would provide large quantities of material at a much lower price than could be obtained in the commercial market.

Potential Commercial Applications: Competitive Advantages:
  • Diagnostic assay for the detection of HIV-1
  • Research tool used to study HIV-1
 
  • Inexpensive antibodies to HIV-1 core proteins
  • Larger source of HIV-1 monoclonal antibodies


Development Stage:
  • In vitro data available
  • Prototype


Inventors:

Timothy Granade (CDC)  ➽ more inventions...

Chou-Pong Pau (CDC)  ➽ more inventions...

Shon Nguyen (CDC)  ➽ more inventions...

Susan Wells (CDC)  ➽ more inventions...

Sherry Owen (CDC)  ➽ more inventions...

Jason Goldstein (CDC)  ➽ more inventions...

Dennis Bagarozzi (CDC)  ➽ more inventions...


Intellectual Property:
Research Tool - Patent protection is not being pursued for this technology.

Publications:
Workman S, et al. PMID 19482361
Ly TD, et al. PMID 15542143
Miles SA, et al. PMID 8419814
Schupbach J, Boni J. PMID 8366170
Weber B, et al. PMID 9665998

Licensing Contact:
Jeremiah Mitzelfelt,
Email: jeremiah.mitzelfelt@nih.gov
Phone: 301-443-8518

OTT Reference No: E-150-2014/0
Updated: Jun 25, 2015