Cancer-reactive T cells from Peripheral Blood


Adoptive cell therapy (ACT) using genetically engineered T-cell receptors (TCRs) is a promising cancer treatment. These TCRs target genetic mutations unique to patients and play an important role in tumor regression. However, mutation-reactive T-cells and their TCRs can be difficult to identify and isolate from patients. Therefore, we need more efficient methods of isolating mutation-reactive T-cells for use with ACT. 

Researchers at the National Cancer Institute (NCI) have developed a novel method of isolating mutation-reactive T-cells from a patient’s peripheral blood lymphocytes (PBL). The researchers found that mutation-reactive T-cells in the PBL are enriched with various markers including CD8, programmed cell death 1 (PD-1), and T cell immunoglobulin and mucin domain 3 (TIM-3). These T-cells and their TCRs can be isolated from the blood and then administered to patients as a cancer therapeutic.

The National Cancer Institute, Surgery Branch, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize this method of isolating mutation-reactive T-cells from peripheral blood.



Potential Commercial Applications: Competitive Advantages:

• Personalized immunotherapy to treat cancer patients
• Research tool to identify T-cells and TCRs targeting patient-specific mutation

 

• Applicable to patients without tumors available for resection
• More cost effective compared to surgical resection for procurement of tumor infiltrating lymphocytes



Development Stage:
Pre-clinical (in vivo)

Related Invention(s):
E-229-2014
E-233-2014
E-269-2015


Inventors:

Steven Rosenberg (NCI)  ➽ more inventions...

Alena Gros (NCI)  ➽ more inventions...


Intellectual Property:
US Provisional Patent Application No. 62/155,830
International Patent Application No. PCT/US2016/030137

Publications:
Gros A, et al, Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients. PMID 26901407
Gros A, et al. PD-1 identifies the patient-specific CD8⁺ tumor-reactive repertoire infiltrating human tumors. PMID 24667641

Collaboration Opportunity:

Licensing and research collaboration


Licensing Contact:
John Hewes, Ph.D.
Email: John.Hewes@nih.gov
Phone: 240-276-5515

OTT Reference No: E-149-2015
Updated: Feb 16, 2018