A Specialized Tissue Collection Device for the Preservation and Transportation of Needle Biopsies


The ability to hold and transport tissue, especially needle biopsies in a pre-defined and controlled environment is critical for the preservation of biopsy samples in downstream analytic applications. Currently, tissue specimens are placed in open containers with variable, poorly controlled solutions applied to them, often in less than sterile conditions.  Evaluation of the tissue by examination through a stereoscope or similar approaches to determine adequacy is limited and requires manipulation of the tissue that can further damage the tissue. The entire process lacks standardization, which is in stark contrast to the handling of blood, that is collected and transported in well-defined containers that have individualized pre-analytic preservatives and downstream protocols. 
 
Researchers at National Institutes of Health (NIH) have developed a tissue collection and storage container that allows for the direct deposition of tissue into the container while stabilizing the sample for transport in a specific solution and/or gas. This new device will primarily be used for needle biopsies to collect tissue samples and maintain their integrity for subsequent analysis. Additional features of the tissue storage container will include materials to physically stabilize and allow for direct examination of the sample by microscopy.

This system is available for co-development or licensing to interested companies.



Potential Commercial Applications: Competitive Advantages:
  • Tissue storage container for collecting samples obtained by biopsy gun, manual biopsy, or interventional radiology such as computed tomography (CT)-guided transvascular, transcutaneous, transvascular sampling, or needle aspiration
  • Sterile and controlled storage environment for the transport of tissue, cell, and liquid samples. Can be combined with the tissue fixative agent, BE70 [NIH Reference # E-139-2015]
 
  • No devices currently allow for tissue storage in a sterile, pre-defined, and controlled environment, and can be used to prepare the sample for further analysis


Development Stage:
Prototype

Related Invention(s):
E-139-2015
E-173-2015


Inventors:

Stephen Hewitt (NCI)  ➽ more inventions...

Robert Star (NIDDK)  ➽ more inventions...

Jeffrey Hanson (NCI)  ➽ more inventions...

Hiroshi Kojima (NIDDK)  ➽ more inventions...

Russell Bandle (NCI)  ➽ more inventions...

Armando Filie (NCI)  ➽ more inventions...


Intellectual Property:
Application No. 62/490,415
Application No. PCT/US2018/029623

Collaboration Opportunity:

Licensing and research collaboration


Licensing Contact:
John Hewes, Ph.D.
Email: John.Hewes@nih.gov
Phone: 240-276-5515

OTT Reference No: E-128-2017
Updated: Sep 5, 2018