Dual Specific Anti-CD22 Anti-CD19 Chimeric Antigen Receptors


Chimeric antigen receptors (CARs) combine an antibody-based binding domain (and single chain fragment variable region, scFv) with T cell receptor signaling domains (CD3 zeta with a costimulatory domain, typically CD28 or 41BB). When T cells express CARs, they are activated in a major histocompatibility complex- (MHC-) independent manner to kill tumor cells expressing the target to which the scFv binds.  CAR T cells targeting the B cell antigen CD19 have resulted in remissions in 60-80% of patients with pre-B cell precursor acute lymphoblastic leukemia (BCP-ALL). However, not all patients respond, and relapses occur in 10% or more of patients who receive anti-CD19 CAR therapy for acute lymphoblastic leukemia (ALL) - primarily due to the loss of the CD19 epitope. Thus, there is a need for advanced therapeutic options to treat those patients who either relapse or are non-responders.
  
To overcome these current limitations, the National Cancer Institute’s Pediatric Oncology Branch (NCI POB) developed an active CD19/CD22 targeted CAR that is potent at eradicating ALL in xenograft studies (Haso et al, Blood, 2013); a Phase I clinical trial is planned. Targeting two antigens simultaneously could increase CAR potency and prevent antigen-loss escape.
The inventors are interested in co-development or licensing opportunities for this technology.



Potential Commercial Applications: Competitive Advantages:
  • Treatment of acute lymphoblastic leukemia (ALL), the most common form of cancer for children ages 1 to 7 years old and afflicts roughly 3000‐3500 persons annually in the US. In 2013, the US had the largest market with a market share of approximately 55% to 60% of the acute lymphocytic/lymphoblastic leukemia therapeutics market in G8 countries, followed by Germany and Italy  
  • Treatment of general hematological cancers
  • Adoptive immunotherapy
 
  • Large market for immunotherapies to treat ALL, an aggressive form of leukemia that occurs in adults and children 


Development Stage:
Pre-clinical (in vivo)

Related Invention(s):
E-291-2012
E-2-65-201



Inventors:

Terry Fry (NCI)  ➽ more inventions...


Intellectual Property:
Application No. 15/559,485

Publications:
Haso W, et al. Anti-CD22–chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia.  PMID 23243285

Collaboration Opportunity:

Licensing and research collaboration


Licensing Contact:
John Hewes, Ph.D.
Email: John.Hewes@nih.gov
Phone: 240-276-5515

OTT Reference No: E-106-2015
Updated: Aug 2, 2018