Transgenic Mouse Model of Human Open Angle Glaucoma

Glaucoma is a group of chronic neurodegenerative disorders, which is characterized by progressive loss of retinal ganglion cells (RGC) and results in irreversible damage to optic nerve and thereby loss of vision. Primary open angle glaucoma (POAG) is the most common form of glaucoma; mutations in MYOC gene are the most common genetically defined cause of POAG. As such, MYOC transgenic mouse models are very useful to study MYOC-associated glaucoma and to develop therapies to treat these diseases.

The NIH inventors generated a new MYOC mouse model carrying a mutant human MYOC (Y437H) gene. The Y437H mutation is associated with a severe form of glaucoma among the identified MYOC mutations.

Potential Commercial Applications: Competitive Advantages:
  • Research tools
  • Drug development for glaucoma
  • The new transgenic mouse model carries a mutation associated with a severe form of glaucoma in humans.

Development Stage:


Stanislav Tomarev (NEI)  ➽ more inventions...

Yu Zhou (NEI)  ➽ more inventions...

Oleg Grinchuk (NEI)  ➽ more inventions...

Intellectual Property:
Research Tool - Patent protection is not being pursued for this technology.

Zhou Y, et al. PMID 18436825
Joe MK, Tomarev SI. PMID 20382707
Chou TH, et al. PMID 25125600

Licensing Contact:
Edward (Tedd) Fenn, J.D.
Phone: 240-276-6833

OTT Reference No: E-091-2015/0
Updated: Jul 2, 2015