Polyclonal Anti-Rat Acetylserotonin Methyltransferase (ASMT)

Rabbits were immunized with peptide corresponding to residues 308-321 of rat ASMT.  Human ASMT and ASMT of other species do  not have this sequence and the anti-ASMT would be specific for the rat ASMT.  Antibody specificity to the peptide used as immunogen was verified by blocking the antibody’s reactivity with pineal gland tissue with the immunogen.  In western blot, the rabbit anti-ASMT serum only reacts with pineal gland and retinal tissue and identifies a band corresponding to the size of the predicted protein.  In immunohistochemistry, the reagents only identify pinealocytes.

Potential Commercial Applications: Competitive Advantages:
  • Useful in detecting rat acetylserotonin methyltransferase in immunological assays, including western blot and immunohishtochemistry.
  • Serum only reacts with pineal gland and retinal tissu

Development Stage:
Discovery (Lead Identification)


David Klein (NICHD)  ➽ more inventions...

Steven Coon (NICHD)  ➽ more inventions...

Intellectual Property:

Steven L. Coon pubmed: 26950199
M.F. Rath et al. PMID: 26950199
F.G. Amara et al. PMID: 26950199
M. Møller PMID: 26950199
D.C. Klein PMID: 26950199

Collaboration Opportunity:

Licensing only

Licensing Contact:
John Hewes, Ph.D.
Email: John.Hewes@nih.gov
Phone: 240-276-5515

OTT Reference No: E-059-2016
Updated: Apr 3, 2018