Gene Signature for Predicting Solid Tumors Patient Prognosis


HCC is the most frequent malignant tumor in the liver and the third leading cause of cancer death worldwide.  A progressive sequence of somatic mutations and epigenetic changes of oncogenes or tumor suppressor genes are believed to cause tumor development. However, high genomic instability in tumors causes the accumulation of genomic aberrations that do not contribute to tumor progression. Therefore, it is important to distinguish between ''driver'' mutations that are functionally important and ''passenger'' mutations that do not provide a selective advantage to the tumor cells.

The current invention describes a driver gene signature for predicting survival in patients with solid malignancies including HCC and breast cancer.  The gene signature includes ten cancer-associated genes, and the NIH researchers further discovered that a decrease in DNA copy number or mRNA expression of some genes is associated with poor prognosis in HCC tumors and breast cancer, while a decrease in DNA copy number or mRNA expression of a few other genes is associated with good prognosis. They have also demonstrated that at least four of these cancer-associated genes are functional tumor suppressor genes. Thus, these genes may be potential molecular targets of HCC and breast cancer.
 



Potential Commercial Applications: Competitive Advantages:
  • Prognosis for hepatocellular carcinoma (HCC) and breast cancer patient survival.
  • Potential new method to identify therapeutic treatment for HCC and breast cancer patients.
 
  • A novel prognostic tool for HCC and breast cancer patients.


Development Stage:
Pre-clinical (in vivo)

Related Invention(s):

E-209-2008
E-215-2007


Inventors:

Xin Wang (NCI)  ➽ more inventions...

Stephanie Roessler (NCI)  ➽ more inventions...


Intellectual Property:
US Application No. 13/127,701
EP Application No. 9752261

Collaboration Opportunity:

Licensing and research collaboration


Licensing Contact:
John Hewes, Ph.D.
Email: John.Hewes@nih.gov
Phone: 240-276-5515

OTT Reference No: E-024-2009
Updated: Jul 19, 2018