A Nurr1-Knockout Mouse Model for Parkinson's Disease and Stem Cell Differentiation


The researchers have generated Nurr1-knockout mice via genomic locus inactivation using homologous recombination.

Transcription factor Nurr1 is an obligatory factor for neurotransmitter dopamine biosynthesis in ventral midbrain. From a neurological and clinical perspective, it suggests an entirely new mechanism for dopamine depletion in a region where dopamine is known to be involved in Parkinson's disease. Activation of Nurr1 may be therapeutically useful for Parkinson's disease patients; therefore, the mice would be useful in Parkinson's disease research.

Additionally, Nurr1 has been shown to be critical for development of midbrain dopaminergic neurons, and thus may contribute to stem cell-based therapies for neurological disorders. Nurr1 is also important for osteoblast differentiation, suggesting a general role in stem cell differentiation and growth.

Potential Commercial Applications: Competitive Advantages:
  • Research and drug testing for Parkinson's disease and other neurological disorders
  • Stem cell research relating to neurological and other disorders and bone formation
 


Inventors:

Vera Nikodem (NIDDK)  ➽ more inventions...


Intellectual Property:
HHS Reference Nos. E-024-1999/0 and E-172-2006/0 -- Research Material. Patent protection is not being pursued for this technology.

Publications:
Lee MK, Choi H, Gil M, Nikodem VM. Regulation of osteoblast differentiation by Nurr1 in MC3T3-E1 cell line and mouse calvarial osteoblasts. J Cell Biochem. 2006 Oct 15;99(3):986-994. PubMed: 16741951
Jankovic J, Chen S, Le WD. The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease. Prog Neurobiol. 2005 Sep-Oct, 77(1-2):128-138. PubMed: 16243425

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OTT Reference No: E-024-1999/0
Updated: Aug 31, 2010