Rapid Molecular Assays for Specific Detection and Quantitation of Loa Loa Microfilaremia


The risk of fatal reactions in some infected individuals administered drug treatments for Loa loa infection, and the lack of accurate, convenient, diagnostics for this infection have thwarted efforts to eradicate the disease. Time consuming, labor intensive and training intensive microscope-based analysis of blood samples is the standard available diagnostic for Loa loa infection. This new assay technology introduces an easy to use, species-specific, highly sensitive, diagnostic that is able to be performed with minimal training. Positive test results may be indicated by an easily visualized color change and this test may be run without the need for expensive equipment such as a thermocycler. Because this test is rapid, cost efficient, labor efficient, accurate, and simple to run and read, it may be readily incorporated into portable point-of-care formats. These attributes make it ideally suited for use in locations where Loa loa infection is endemic. These advantages may lead to this technology becoming the new standard for diagnosis of Loa loa infections and a valuable tool, in control programs, to identify risks for adverse treatment reactions.

Potential Commercial Applications: Competitive Advantages:
  • Diagnostics testing
  • Infectious disease monitoring
 
  • Greater speed cost and labor efficiencies, accurate, and simple to run and read and ability to be incorporated into portable point-of-care format, ideally suited for Loa loa endemic regions.


Development Stage:
  • Early-stage
  • Pre-clinical


Related Invention(s):
E-084-2010/0
E-281-2010/0


Inventors:

Thomas Nutman (NIAID)  ➽ more inventions...

Doran Fink (NIAID)  ➽ more inventions...


Intellectual Property:
PCT Application No. PCT/US2011/58565
US Application No. 61/410,232
Available for research use only.

Publications:
Fink DL, et al. PMID 21912716
Klion AD, et al. PMID 2038361

Collaboration Opportunity:

The National Institute of Allergy and Infectious Disease (NIAID) is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize Rapid Molecular Assays for Specific Detection and Quantitation of Loa Loa Microfilaremia. For collaboration opportunities, please contact the NIAID Technology Transfer & Intellectual Property Office at 301-496-2644.


Licensing Contact:
Benjamin Hurley, Ph.D.
Email: benjamin.hurley@nih.gov
Phone: 240-669-5092

OTT Reference No: E-014-2011/0
Updated: May 3, 2016