Encapsulated Streptococcus Compositions and Methods for Pneumococcal Vaccine, Probiotic, and Diagnostic Assay Development


Streptococcus pneumoniae (S. pneumoniae) bacteria, or pneumococcus, can cause many types of illnesses. These range from ear and sinus infections to life-threatening conditions such as pneumonia, bloodstream infections, and meningitis. Pneumococci are surrounded by a polysaccharide capsule, which is thought to help it evade the immune system. Presently, over 90 known serotypes of S. pneumoniae have been identified, of which only a minority produce the majority of pneumococcal infections; a serotype is defined by a unique pneumococcal capsule structure. Currently available vaccines contain antigens made from capsular polysaccharides of 10, 13, or 23 common S. pneumoniae serotypes.

CDC has discovered encapsulated strains of commensal Streptococcus species,S. mitis, S. oralis and S. infantis, that have capsules that are identical to pneumococcal capsules. From this, researchers developed compositions and methods from the species’ biosynthetic capsular genes which show promise for protecting people against pneumococcal disease, either by using these strains as vaccines or probiotics or through development of diagnostic assays. Initial results show cross-protection against eight S. pneumoniae serotypes, including serotype 1, a leading cause of invasive pneumococcal disease globally outside of the US. The capsule components or a modified version of the commensal Streptococcus species could be used to develop a novel live, inactivated or a sub-unit vaccine for S. pneumoniae. Initial concept studies have been performed in animal models.



Potential Commercial Applications: Competitive Advantages:
  • Novel live vaccine or vaccine component to prevent against Streptococcus pneumoniae
  • Therapeutic, probiotic or preventive for other pneumococcal conditions (e.g., ear infections, meningitis, and bacteremia)
  • Vaccine-related assays
  • Diagnostic assays
 
  • May be prepared in a variety of dosage forms such as solution, solid or powdered (e.g., lyophilized) form
  • Easily adaptable to kit form
  • Vaccine compositions may protect against multiple pneumococcal organisms or be tailored for specific serotypes affecting a particular population
  • May address drawbacks of currently available S. pneumoniae vaccines where certain populations do not respond optimally to vaccine antigens


Inventors:

Bernard Beall (CDC)  ➽ more inventions...

Cynthia Whitney (CDC)  ➽ more inventions...

Maria Da Gloria Carvalho (CDC)  ➽ more inventions...

Fabiana Pimenta (CDC)  ➽ more inventions...

Fernanda Lessa (CDC)  ➽ more inventions...

Jennifer Miluck (CDC)  ➽ more inventions...

Monica Farley


Intellectual Property:
US Application No. 62/627,602

Publications:

Pimenta F. et al.

PMID 30671034

Collaboration Opportunity:

The CDC Technology Transfer Office (TTO) is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize: Encapsulated Streptococcus Compositions & Methods for Pneumococcal Vaccine, Probiotic and Diagnostic Assay Development. For collaboration opportunities, please contact CDC TTO at tto@cdc.gov or 1-404-639-1330.




Licensing Contact:
Karen Surabian, J.D., M.B.A.
Email: karen.surabian@nih.gov
Phone: 301-594-9719

OTT Reference No: E-009-2018-0
Updated: Feb 26, 2019