Serotonin-Deficient Knock-out Mouse


Serotonin is an important modulator of many developmental, behavioral, and physiological processes, and it has been implicated in depression, anxiety, schizophrenia, obsessive compulsive disorders, and substance abuse. Serotonin’s pharmacology is extremely complex and it is mediated by seven of serotonin receptor subtypes and it is present in several tissues. Although it has been a subject of a number of studies, its role has been difficult to ascertain. To investigate the role of serotonin in these disorders, the murine gene was disrupted by homologous recombination. Results indicate that serotonin binding sites were absent in different brain regions (brain stem, frontal cortex, hippocampus, and striatum), and its concentrations were reduced by 60-80%. These mice represent a powerful tool for the investigation of behavioral and neuropsychiatric disorders, and development of drug treatments for these disorders.

Potential Commercial Applications: Competitive Advantages:
  • A model to study serotonin’s role in behavioral and neuropsychiatric disorders.
 


Inventors:

Dennis Murphy (NIMH)  ➽ more inventions...


Intellectual Property:
Research Tool -- Patent protection is not being pursued for this technology.

Publications:
Ren-Patterson RF, et al. PMID 15672416
Murphy DL, et al. PMID 15087484
Ren-Patterson RF, et al. PMID 15972295
Li Q, et al. PMID 15574737
Kilic F, et al. PMID 12869649
Murphy DL, et al. PMID 14653307
Ozaki N, et al. PMID 14593431

Licensing Contact:
Jennifer Wong, M.S.
Email: jennifer.wong2@nih.gov
Phone: 301-480-4821

OTT Reference No: B-019-1999-0
Updated: Jun 5, 2018