Photoactivatable Lipid-based Nanoparticles as a Vehicle for Dual Agent Delivery
The invention relates to novel lipid-based nanoparticles (liposomes) for use in targeted, on demand and on site drug delivery. The particles include a wall surrounding a cavity, wherein the wall is comprised of:
- A lipid bilayer comprising 1,2-bis(tricosa-10,12-diynoyl)-sn-glycero-3-phosphocholine (DC8,9PC), dipalmitoylphosphatidylcholine (DPPC), and 1,2-distearoyl-sn-glycero-3-
phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (DSPE-PEG2000), and
- A tetrapyrollic photosensitizer, 2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a (HPPH) within the lipid bilayer.
The photosensitive lipid nanoparticles are capable of containing water-soluble agents (e.g., topotecan) in their cavity and designed to be 80-200nm in diameter. The release of agents is triggered by the disruption of the lipid bilayer when light (near-infrared wavelength of 650-670nm) is discretely applied. The concurrent activation of the photosensitizing agent, HPPH may be advantageous in the treatment of certain cancers, especially since this agent possesses therapeutic ability. The inventors have also shown the cytotoxicity of the lipid nanoparticles in T24 bladder cancer cells in the presence and absence of light, drug, and HPPH. The lipid nanoparticles containing the water-soluble agent, topotecan, and HPPH, in the presence of light exhibit superior toxicity as compared to either lipid-nanoparticle encapsulated topotecan or HPPH alone.
Potential Commercial Applications: | Competitive Advantages: |
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Development Stage:
Pre-clinical (in vivo)
Inventors:
Anu Puri (NCI) ➽ more inventions...
Robert Blumenthal (NCI) ➽ more inventions...
Amit Joshi (NCI) ➽ more inventions...
Darayash Tata (NCI) ➽ more inventions...
Mathias Viard (NCI) ➽ more inventions...
Intellectual Property:
Collaboration Opportunity:
Licensing and research collaboration
Licensing Contact:
John Hewes, Ph.D.
Email: John.Hewes@nih.gov
Phone: 240-276-5515
OTT Reference No: E-482-2013
Updated: Aug 15, 2017