Magnetic Resonance Specimen Evaluation Using Multiple Pulse Field Gradient Sequences


The invention proposes and claims an MRI-method that is based on the measurement and acquisition of multiple pulsed field gradient (m-PFG) rather than the previously used single-pulsed field gradient (s-PFG) MRI sequences. In particular, double PFG (d-PFG) sequences offer higher sensitivity and greater robustness, as it is more sensitive to the effect of “restriction”, i.e., to water trapped within the axon’s intracellular space, and thus to the diameter of the axons. It renders the MR sequence more sensitive to “pore size” and “pore shape” and thus makes the measurement of the ADD more sensitive and accurate. Moreover, measurements using the multiple-PFG sequence can be performed readily at “low b” or “low q”, making it biologically relevant and clinically feasible.

A detailed announcement describing the licensing opportunity for this and related technologies referenced below was published in the Federal Register on Tuesday, April 14, 2009 (74 FR 17199-17201).

Development Stage:
Invention is fully developed.

Related Invention(s):
E-203-1993/0
E-079-2003/0
E-079-2003/1


Inventors:

Peter Basser (NICHD)  ➽ more inventions...

Evren Ozarslan (NICHD)  ➽ more inventions...


Intellectual Property:
U.S. Pat: 8,704,515 issued 2014-04-22
US Application No. 12/539,462

Publications:
Özarslan E, Basser PJ. PMID 18433239
Komlosh ME, et al. PMID 18383293
Özarslan E, Basser PJ. PMID 17723314
Komlosh ME, et al. PMID 17869147
Komlosh ME, et al. Detection of microscopic anisotropy in gray matter using d-PGSE. In Proc Intl Soc Mag Reson Med. 2005;13:843. PDF
Komlosh ME, et al. Detection of local anisotropy using double-PGSE filtered imaging. In 47th Experimental Nuclear Magnetic Resonance Conference, 2006. PDF
Özarslan E, Basser PJ. Diffusion-Diffraction Phenomenon in multi-PFG experiments. In Science Networking Development Scheme Meeting. Ein-Boqeq, Israel, 2007. PDF
Komlosh ME, et al. Observation of microscopic diffusion anisotropy in the spinal cord using double-pulsed gradient spin echo MRI. In Proc Intl Soc Mag Reson Med. 2008;16:763. PDF
Özarslan E, Basser PJ. Microscopic anisotropy revealed by double-PFG NMR. In 9th International Bologna Conference on Magnetic Resonance in Porous Media 2008; p. 26. PDF
Özarslan E, et al. Double-PFG diffusion-diffraction in ellipsoidal pores. In 9th International Bologna Conference on Magnetic Resonance in Porous Media 2008; p. 115. PDF

Collaboration Opportunity:

The Eunice Kennedy Shriver National Institute of Child Health and Human Development, Section on Tissue Biophysics and Biomimetics, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize novel MRI methods to probe tissue structure and organization, particularly for neuroimaging applications. Please contact Alan Hubbs, Ph.D. at 240-276-5532 or hubbsa@mail.nih.gov for more information.


Licensing Contact:
Surekha Vathyam, Ph.D.
Email: vathyams@mail.nih.gov
Phone: 240-276-6865

OTT Reference No: E-276-2008/0
Updated: Sep 22, 2015