Human Rotavirus Strains and Vaccines for Neonatal Childhood Protection


This invention relates to rotavirus vaccine compositions and methods of vaccination. Rotaviral infection is the most commonly occurring gastrointestinal illness of children world, affecting both developed and developing economies. Additionally, rotavirus infections can affect livestock (especially calves and piglets), and resulting mortality/morbidity cause major economic losses for farmers and nations each year.

The vaccine strains include Rotavirus A CDC-9 (P[4]Gl) and CDC-66 (P[4]G2 serotype). These strains represent common rotavirus serotypes and may serve as improvements or alternatives to current live, oral rotavirus vaccine strains. Further, this technology has demonstrated efficacy in a large animal (piglets) modeling.

Potential Commercial Applications: Competitive Advantages:
  • Novel rotavirus vaccines
  • Neonatal/childhood vaccination initiatives
  • Rotavirus surveillance programs, important for both developing and developed nations
 
  • Isolated strains are representative of those involved in community-acquired infection
  • Suitable for the development of improved, broadly effective rotavirus vaccines
  • Can be developed for injection and/or oral vaccine administration
  • Derived vaccines may be administered alone or in combination with other vaccines


Development Stage:
  • In vitro data available
  • In vivo data available (animal)


Related Invention(s):
E-122-2013-0
E-153-2013-0
E-191-2013-2
E-521-2013-0


Inventors:

Baoming Jiang (CDC)  ➽ more inventions...

Roger Glass (CDC)  ➽ more inventions...

Yuhuan Wang (CDC)  ➽ more inventions...

Jon Gentsch (CDC)  ➽ more inventions...


Intellectual Property:
U.S. Pat: 8,822,192 issued 2014-09-02
U.S. Pat: 9,498,526 issued 2016-11-22
US Application No. 13/320,095
US Application No. 15/200,837
US Application No. 14/461,663
US Application No. 15/956,662
Various international filings pending or deferred

Publications:
Esona MD, et al. [PMID 20009519]
Wang Y, et al. [PMID 20558244]
Jiang B, et al. [PMID 23744507]

Licensing Contact:
Karen Surabian, J.D., M.B.A.
Email: karen.surabian@nih.gov
Phone: 301-594-9719

OTT Reference No: E-150-2013-0
Updated: Feb 13, 2014