Technology ID
E-765-2013

Multifunctional RNA Nanoparticles as Cancer and HIV Therapeutics

Linked ID
NCI-E-765-2013
Inventors
Angelica Martins ()
Bruce Shapiro (NCI)
Kirill Afonin ()
Mathias Viard ()
Lead Inventors
Bruce Shapiro (NCI)
Co-Inventors
Angelica Martins ()
Kirill Afonin ()
Mathias Viard ()
Development Stages
Pre-clinical (in vivo)
Development Status
Pre-clinical (in vivo)
Applications
Therapeutics
ICs
NCI
Commercial Applications
  • Treatment for cancer and HIV
The promise of RNA interference based therapeutics is made evident by the recent surge of biotechnological drug companies that pursue such therapies and their progression into human clinical trials. The present invention discloses novel RNA and RNA/DNA nanoparticles including multiple siRNAs, RNA aptamers, fluorescent dyes, and proteins. These RNA nanoparticles are useful for various nanotechnological applications. This technology has a higher detection sensitivity and higher silencing efficiencies of targeted genes than conventional siRNAs. This technology has significant therapeutic potential against multiple disease types, including, cancer and viral infections. Xxenograft mouse models indicated uptake of the nanoparticles, and six different HIV targets were validated with cell cultures.
Competitive Advantages
  • Potential for higher sensitivity, higher efficiency, low cytotoxicity, multiple functionality, multiple targets, and controlled activation

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