Technology ID
E-314-2013-0

Octopod (8-Pointed Star) Iron Oxide Nanoparticles Enhance MRI T2 Contrast

Linked ID
TAB-2898
Inventors
Jinhao Gao (Xiamen University)
Xiaoyuan Chen (NIBIB)
Zhenghuan Zhao (Xiamen University)
Lead Inventors
Xiaoyuan Chen (NIBIB)
Co-Inventors
Jinhao Gao (Xiamen University)
Zhenghuan Zhao (Xiamen University)
Development Stages
Pre-clinical (in vivo)
Development Status
In vivo data available (animal)
ICs
NIBIB
Commercial Applications
  • Medical imaging, such as tumor detection, atherosclerosis imaging and delivery of therapeutic treatments.
The octopod-shaped iron oxide nanoparticles of this technology significantly enhance contrast in MRI imaging compared to spherical superparamagnetic iron oxide nanoparticle T2 contrast agents. These octopod iron oxide nanoparticles show a transverse relaxivity that is over five times greater than comparable spherical agents. Because the unique octopod shape creates a greater effective radius than spherical agents, but maintains similar magnetization properties, the relaxation rate is improved. The improved relaxation rate greatly enhances the contrast of images. These octopod agents appear to be bio-compatible and may be suitable for intravenous delivery. The synthesis of these agents is also easily reproducible and scaled. The superior contrast greatly improves diagnostic sensitivities, compared to current FDA approved spherical contrast agents. These octopod-shaped iron oxide nanoparticle T2 contrast agents may have a number of medical imaging uses, such as tumor detection, atherosclerosis imaging and delivery of therapeutic treatments.
Competitive Advantages
  • Enhanced T2 contrast
  • Reproducible and scalable synthesis
  • Improved imaging and diagnostic capability

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