Technology ID
E-314-2002-0

Regulation of RNA Stability

Linked ID
TAB-830
Inventors
Elizabeth Kennington (NIEHS)
Perry Blackshear (NIEHS)
Wi Lai (NIEHS)
Lead Inventors
Wi Lai (NIEHS)
Co-Inventors
Elizabeth Kennington (NIEHS)
Perry Blackshear (NIEHS)
Applications
Research Materials
ICs
NIEHS
This invention relates to the discovery that tristetraprolin (TTP) can promote the poly(A)RNase (PARN) mediated deadenylation of polyadenylated substrates containing AU-rich elements (AREs). As one aspect of the invention, the inventors have developed a cell free system that may be used for the purposes of assessing the effects of the various system components or their derivatives (i.e. AREs, PARN, or TTP) on the deadenylation process or the effects of various test agents on the deadenylation process. {RefNo is 830 }

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