Technology ID
E-293-2014-1

Heartland Virus Humanized Monoclonal Antibodies for Diagnostic and Therapeutic Development

Linked ID
TAB-3243
Inventors
Aaron Brault (CDC)
Amanda Calvert (CDC)
Lead Inventors
Amanda Calvert (CDC)
Co-Inventors
Aaron Brault (CDC)
Development Stages
Prototype
ICs
CDC
Commercial Applications
  • Development of immunoassay diagnostics in IgG and IgM ELISA formats and other serological diagnostics (e.g., immunofluorescence, multi-bead array, and lateral flow assays for point of care diagnostics) for Heartland virus infections
  • Development of immunoassay diagnostics for the detection of severe fever with thrombocytopenia syndrome virus (SFTSV), another tick-borne virus similar to HRTV
  • Research tools to characterize this newly discovered virus which causes severe diseases in humans
  • Tick-borne virus monitoring programs
  • Development of therapeutics to treat Heartland virus infections in humans
Competitive Advantages
  • The only characterized antibodies against HRTV
  • Potential use as a diagnostic, therapeutic, or research tool
  • Differentiation between recent and past infections
  • Ability to perform diagnostic assay without biosafety level 3 containment
  • Currently, no diagnostic tests exist for HRTV except for plaque reduction neutralization tests
  • MAb 2AF11 is the only mAb available in the U.S. that recognizes both HRTV and SFTSV, the latter which has caused several thousand cases of severe disease throughout China, Korea and Japan

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