Technology ID
E-279-2001-0

Stem Cell Factor-responsive FcepsilonRI Bearing Human Mast Cell Line LAD2

Linked ID
TAB-641
Inventors
Arnold Kirshenbaum (NIAID)
Cem Akin (NIAID)
Dean Metcalfe (NIAID)
Lead Inventors
Arnold Kirshenbaum (NIAID)
Co-Inventors
Cem Akin (NIAID)
Dean Metcalfe (NIAID)
Applications
Research Materials
ICs
NIAID
Commercial Applications
  • A research material that can be used in the development of assays, validation of products or in quality control.
A human mast cell line LAD2 that more closely resembles normal in vivo and in vitro human mast cells by expressing functional FcepsilonRI receptors and responding to stem cell factor (SCF) with proliferation, as described in Leuk Res. 2003 Aug;27(8):677-82 and developed by the laboratory of Dr. Dean Metcalfe at the National Institute of Allergy and Infectious Diseases.  This cell line also releases mediators by cross-linking FcgammaRI (CD64) receptors and express FcgammaRII (CD32).
Competitive Advantages
  • Speed up product development with NIH developed material that has already been tested and validated.

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