Technology ID
E-210-2013-0

Novel Epitopes of Bacillus anthracis Lethal Factor for Development of Diagnostics and Therapeutics

Linked ID
TAB-2694
Inventors
Anne Boyer (CDC)
Conrad Quinn (CDC)
Dennis Bagarozzi (CDC)
Jason Goldstein (CDC)
Lead Inventors
Jason Goldstein (CDC)
Co-Inventors
Anne Boyer (CDC)
Conrad Quinn (CDC)
Dennis Bagarozzi (CDC)
Development Stages
Pre-Clinical (in vitro)
Development Status
  • Early-stage
  • In vitro data available
Therapeutic Areas
Infectious Disease
ICs
CDC
Commercial Applications
  • Diagnostic tests assessing active Lethal Factor in a sample
  • Anthrax neutralizing therapeutics and vaccines for B. anthracis
  • Biodefense, biosecurity
CDC researchers have characterized epitopes of Bacillus anthracis Lethal Factor (LF), a critical component of the B. anthracis lethal toxin. These epitopes may allow for development of therapeutics for the treatment or prevention of B. anthracis infection. They may also allow screening for B. anthracis LF in a sample and development of a peptide anthrax vaccine.
Competitive Advantages
  • Potentially faster, lower-input assay compared to current Edema Factor detection methods
  • Easily adaptable for high-throughput screening of numerous specimens

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