Technology ID

Real-Time PCR for Detecting Legionella Species and Discriminating Legionella pneumophila

Linked ID
Brian Holloway (CDC)
Karen McCaustland (CDC)
Patrick Yang (CDC)
Robert Benson (CDC)
Lead Inventors
Patrick Yang (CDC)
Brian Holloway (CDC)
Karen McCaustland (CDC)
Robert Benson (CDC)
Development Status
  • Early-stage
  • In vitro data available
Therapeutic Areas
Infectious Disease
Commercial Applications
  • Diagnostic for Legionnaires’ disease
  • Detection of all Legionella species and specific discrimination of L. pneumophila
Legionella pneumophila is the causative species in most cases of Legionnaires' disease (LD). CDC scientists have developed a real-time PCR assay capable of detecting all Legionella species and discriminating L. pneumophila from other Legionella species. LD is typically difficult to diagnose from a clinical standpoint as it confers no unique clinical features or symptoms. This assay provides a rapid and accurate alternative to laborious PCR assays, prone to aberrant results. It provides a sensitive alternative for diagnosis of Legionnaires' disease and detection of L. pneumophila.
Competitive Advantages
  • Faster than immunoassays
  • Less laborious than current LD diagnostics
  • Rapid, sensitive, and specific
  • Curtails misdiagnoses associated with serological evaluations
  • Easily adaptable to kit form

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