Technology ID
E-158-2015-0

Metallic Nanoparticles for Photothermal Therapy

Linked ID
TAB-2993
Inventors
Jibin Song (NIBIB)
Xiaoyuan Chen (NIBIB)
Lead Inventors
Xiaoyuan Chen (NIBIB)
Co-Inventors
Jibin Song (NIBIB)
Development Stages
Pre-Clinical (in vitro)
Development Status
In vitro data available
ICs
NIBIB
Commercial Applications
  • Cancer therapy
  • Tumor therapy
The invention relates to the preparation and application of 20-150nm metallic nanoparticulate vesicles for photothermal anti-cancer therapy. The vesicles comprise metallic nanoparticles covalently bound to a hydrophilic and hydrophobic polymer. The preparation method generally entails dispersing a polymer-bound metallic nanoparticle in an organic solvent, adding an aqueous solution with a dispersing aid, sonicating the mixture, and finally removing the organic solvent until the vesicle forms. The final vesicle is stable wherein the metallic nanoparticle is covalently bound to the hydrophobic and hydrophilic polymer. By way of a non-limiting example, an exemplary vesicles can be one made from gold nanorods coated with polyethylene glycol and polylactic-co-glycolic acid (AuNR@PEG/PLGA) in an oil-in-water emulsion.
Competitive Advantages
  • Prolonged circulation
  • High tumor accumulation
  • Rapid excretion
  • Enhanced photoacoustic signal
  • Enhanced photothermal effect/cancer therapy efficacy

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