Technology ID
E-157-1991-0

Antigen, Encoding Gene, Related Monoclonal Antibody and Hybridoma Clones for Streptococcus pneumoniae Serological Diagnostics

Linked ID
TAB-2730
Inventors
Harold Russell (CDC)
Jacquelyn Sampson (CDC)
Steven O'connor (CDC)
Lead Inventors
Harold Russell (CDC)
Co-Inventors
Jacquelyn Sampson (CDC)
Steven O'connor (CDC)
Development Stages
Pre-Clinical (in vitro)
Development Status
In vitro data available
Therapeutic Areas
Infectious Disease
ICs
CDC
Commercial Applications
  • Screening diagnostic young, elderly and immunocompromised patients for possible S. pneumoniae infection
  • Pneumococcal disease vaccine development or refinement
This CDC developed invention pertains to Streptococcus pneumoniae protein "pneumococcal fimbrial protein A (PfpA)," as well as the encoding pfpA gene. S. pneumoniae linked pneumococcal disease is prevalent among the very young, the elderly and also immunocompromised individuals. This invention covers the breadth of directly PfpA-related technology that might be employed for development of diagnostic tests for S. pneumoniae and/or vaccines directed against the pathogen. In addition to the the intellectual property protected amino acid sequence and encoding plasmid, monoclonal antibodies and corresponding hybridomas are also available.
Competitive Advantages
  • Easily adapted to a high-throughput assay for mass screening purposes
  • Can be formatted as an on-site, lateral-flow diagnostic; both PfpA antigen and anti-PfpA mAb are available

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