Technology ID
E-070-2013

Silicone Hydrogel Support Structures that Mimic Tissue Vasculature for Cell Culturing

Linked ID
NCI-E-070-2013
Inventors
Ashley Jaeger (CIT)
Chandan Das (NCI)
Michael Gottesman (NCI)
Nicole Morgan (NIBIB)
Philip Mcqueen (CIT)
Randall Pursley (CIT)
Thomas Pohida (CIT)
Lead Inventors
Chandan Das (NCI)
Co-Inventors
Ashley Jaeger (CIT)
Michael Gottesman (NCI)
Nicole Morgan (NIBIB)
Philip Mcqueen (CIT)
Randall Pursley (CIT)
Thomas Pohida (CIT)
Development Stages
Prototype
Development Status
Prototype
Applications
Diagnostics
ICs
NIBIB
NCI
CIT
Commercial Applications
  • Tissue engineering
  • Simulation of physiological growth conditions
Researchers at the National Cancer Institute developed silicone hydrogel support structures that mimic tissue vasculature (e.g., capillary bed) with high oxygen diffusivity. Photolithographic methods are used to construct mimetic silicone hydrogel pillars that have, for example, a 20:1 height to diameter ratio. Advantageously, these mimetic silicone hydrogels diffuse oxygen from the bottom chamber to the cells cultured on the surface at near physiological rates (60 times that of water). Uses of these mimetics include 2-D screening for chemotherapeutic compounds and growth of tissue for grafting.
Competitive Advantages
  • High oxygen diffusivity

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