Technology ID
E-066-2012-0

Dipicolylamine-based Nanoparticles for Delivery of Ligands

Linked ID
TAB-2635
Inventors
Gang Liu (NIBIB)
Ki Young Choi (NIBIB)
Seulki Lee (NIBIB)
Xiaoyuan Chen (NIBIB)
Lead Inventors
Xiaoyuan Chen (NIBIB)
Co-Inventors
Gang Liu (NIBIB)
Ki Young Choi (NIBIB)
Seulki Lee (NIBIB)
Development Status
  • Early-stage
  • In vivo data available (animal)
Applications
Therapeutics
ICs
NIBIB
Commercial Applications
  • Drug delivery
  • Gene therapy
Many potential nucleic acid therapeutics have not transitioned from the research laboratory to clinical application in large part because delivery technologies for these therapies are not effective. Most nucleic acid delivery technologies are lipid-based or positively charged and require chemical or physical conjugation with the nucleic acid. These delivery systems are often therapeutically unacceptable due to toxicity or immune system reactivity. The present technology is a nanoparticle complex, containing a polymer substrate, such as a hyaluronic acid, and Zn2+-dipicolylamine (Zn-DPA), that associates selectively with the nucleic acid phosphodiester groups. This complex functions as a simple, easy to scale-up, cost effective, low toxicity delivery system for potential nucleic acid therapeutics, such as siRNA molecules. It may also be capable of co-delivering other small molecule drugs.
Competitive Advantages
  • Efficient
  • Easy to scale-up
  • Cost effective
  • Low toxicity

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