Technology ID
E-012-2017-0

Immortalized Organ of Corti Cell Line OC-k3

Linked ID
TAB-3083
Inventors
Frederico Kalinec (NIDCD)
Gilda Canseco De Kalinec (NIDCD)
Lead Inventors
Gilda Canseco De Kalinec (NIDCD)
Co-Inventors
Frederico Kalinec (NIDCD)
Applications
Research Materials
ICs
NIDCD
Commercial Applications
  • Research
  • Hearing research
  • Susceptibility to ototoxic drugs
Available for nonexclusive licensing as a research material is a conditionally immortalized Organ of Corti cell line called OC-k3. Sensory cells from the auditory organ, the Organ of Corti, are terminally differentiated and cannot be cultured. Moreover, few of them can be isolated per cochlea and survive only few hours after isolation making impossible to use on them many biochemical and molecular biology techniques. OC-k3, expresses many markers of sensory cells and it has already been used as an in vitro model for a variety of studies.

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