Technology ID
B-019-1999-0

Serotonin-Deficient Knock-out Mouse

Linked ID
TAB-1514
Inventors
Dennis Murphy (NIMH)
Klaus-pete Lesch (NIMH)
Lead Inventors
Dennis Murphy (NIMH)
Co-Inventors
Klaus-pete Lesch (NIMH)
Applications
Research Materials
Therapeutic Areas
Neurology
ICs
NIMH
Commercial Applications
  • A model to study serotonin’s role in behavioral and neuropsychiatric disorders.
Serotonin is an important modulator of many developmental, behavioral, and physiological processes, and it has been implicated in depression, anxiety, schizophrenia, obsessive compulsive disorders, and substance abuse. Serotonin’s pharmacology is extremely complex and it is mediated by seven of serotonin receptor subtypes and it is present in several tissues. Although it has been a subject of a number of studies, its role has been difficult to ascertain. To investigate the role of serotonin in these disorders, the murine gene was disrupted by homologous recombination. Results indicate that serotonin binding sites were absent in different brain regions (brain stem, frontal cortex, hippocampus, and striatum), and its concentrations were reduced by 60-80%. These mice represent a powerful tool for the investigation of behavioral and neuropsychiatric disorders, and development of drug treatments for these disorders.

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