Product Showcase

Table of Contents

2004
Product Name:
AB3369 Gamma H2A, RBX
Use:
Histones play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.
HHS Contribution:
To provide an antibody that specifically binds to a C-terminal phosphorylated serine in an H2A histone protein
Features:
Routinely evaluated by Western Blot. Has successfully immunoprecipitated phosphorylated H2A.X
Inventors:
W. Bonner
HHS Institute/Agency:
NCI
Licensee:
Chemicon International  
Market Launch:
2004
2003
Product Name:
ABL2 (arg) polypeptide/protein
Use:
Links cell surface receptors to cell proliferation and/or cytoskeletal reorganization
HHS Contribution:
Found ARG, a human gene related to but distinct from ABL proto-oncogene
Features:
Can be used with Omnia® Bulk Substrate, LanthaScreen™ Antibody, Z'-LYTE™ and LanthaScreen™ Substrate kits
Inventors:
G. Kruh, S. Aaronson
HHS Institute/Agency:
NCI
Licensee:
Invitrogen Corporation  
Market Launch:
2003
1998
Product Name:
AcuTect®
Use:
Diagnosis of sudden blood clots in the legs that can cause lung embolisms
HHS Contribution:
Method of synthesizing peptides with reactive side groups
Features:
Specific for acute and not chronic venous thrombosis
Inventors:
F. Robey
HHS Institute/Agency:
NIDCR
Licensee:
Berlex Laboratories, Inc. 
Market Launch:
1998
1998
Product Name:
Alfaxan® - CD RTU
Use:
Injectable anaesthetic for cats and dogs
HHS Contribution:
Adding a cyclodextrin excipient to increase drug solubility
Features:
No allergic reactions compared to other excipients
Inventors:
J. Pitha
HHS Institute/Agency:
NIA
Licensee:
Jurox Pty Ltd. 
Market Launch:
1998
2005
Product Name:
Alliance HIV-1 P24 ANTIGEN ELISA Kit
Use:
For detection of HIV-1 p24 antigen in serum/plasma and cell culture
HHS Contribution:
Discovered the virus HTLV-III in 1984, which is useful in the detection of antibodies in sera of AIDS and pre-AIDS patients.
Features:
Provides reagents for immune complex disruption of antigen/antibody complexes in serum and plasma samples.
Inventors:
R Gallo, Mpopovic
HHS Institute/Agency:
NCI
Licensee:
PerkinElmer Life and Analtyical Sciences, Inc.  
Market Launch:
2005
1992
Product Name:
Anti- Interleukin-2
Use:
Used for the detection of IL-2 of human origin
HHS Contribution:
Disclosed a sandwich method and a kit for assaying interleukin-2 receptor (IL-2R) in a sample.
Features:
Reacts specifically with Human IL-2. Not with other interleukins
Inventors:
Robert Yarchoan, Warren Leonard, David Nelson
HHS Institute/Agency:
NCI
Licensee:
Upstate Biotechnology, Incorporated  
Market Launch:
1992
1996
Product Name:
Anti-HIV: MAB880
Use:
Variety of HIV Antibodies available for research,
HHS Contribution:
Produced monoclonal antibodies in hybridoma cells by fusing myeloma cells with spleen cells from mammals immunized with lysates of purified virus.
Features:
Although not a direct replacement for MAB882, it will meet the needs of many customers
Inventors:
M. Sarngadharan, F. di Marzo Veronese, R. Gallo
HHS Institute/Agency:
NCI
Licensee:
Chemicon International  
Market Launch:
1996
1997
Product Name:
Anti-Human CYP2D6 (recognizes Human CYP2D6)
Use:
Selectively immunoblots CYP2D6
HHS Contribution:
Provides monoclonal antibodies specific to human cytochrome p450 2D6 isoform
Features:
This product is specific against human proteins
Inventors:
H. Gelboin
HHS Institute/Agency:
NCI
Licensee:
Becton, Dickinson and Company  
Market Launch:
1997
1998
Product Name:
Anti-human STAT 6 (872) antibody
Use:
Identify and trace specific cells or molecules in an organism
HHS Contribution:
Developed stat 6 polyclonal antibodies designated 880, 882, 872
Features:
Stat6 is critically involved in Th2 immune response.
Inventors:
W. Larochelle, B. Patel, J. Pierce
HHS Institute/Agency:
NCI
Licensee:
Upstate Biotechnology, Incorporated  
Market Launch:
1998
2001
Product Name:
Anti-phospho-H2A.X (Ser139)
Use:
Histones play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.
HHS Contribution:
Provides an antibody that specifically binds to a C-terminal phosphorylated serine in an H2A histone protein
Features:
Routinely evaluated by Western Blot. Has successfully immunoprecipitated phosphorylated H2A.X
Inventors:
W. Bonner
HHS Institute/Agency:
NCI
Licensee:
Upstate Biotechnology, Incorporated  
Market Launch:
2001
2001
Product Name:
Anti-Phosphorylated Histone H2AX (γ-H2AX) Polyclonal Antibody
Use:
The unique property of H2AX polyclonal antibody is to only detect phosphorylated histones at sites of double-strand DNA breaks.
HHS Contribution:
Provided an antibody that specifically binds to a C-terminal phosphorylated serine in an H2A histone protein
Features:
Thousands of γ-H2AX molecules can be present per double-strand break
Inventors:
W. Bonner
HHS Institute/Agency:
NCI
Licensee:
Trevigen, Inc.  
Market Launch:
2001
1994
Product Name:
Anti-pig Ig monoclonal antibodies
Use:
Used as a research tool to advance appropriate veterinary research and development applications
HHS Contribution:
Produced hybridoma cell lines to pig lymphoid cells
Features:
This ready to use antibody reacts with heavy and light chains
Inventors:
J. Lunney, M. Pescovitz, D. Sachs
HHS Institute/Agency:
NCI
Licensee:
Veterinary Medical Research & Development  
Market Launch:
1994
2001
Product Name:
Anti-TIMP-2 Mouse monoclonal Antibody
Use:
TIMPs are capable of altering the metastatic potential of cancer cells and have been shown to inhibit invasion and metastasis in animal models.
HHS Contribution:
An isolated protein of approximately 23,000 daltons in size that binds to metalloproteinases, and is potentially useful for the detection metalloproteinases.
Features:
Useful for SDS-PAGE/immunoblot standard and inhibition studies.
Inventors:
W. Stetler-Stevenson
HHS Institute/Agency:
NCI
Licensee:
Calbiochem-Novabiochem Corp.  
Market Launch:
2001
1992
Product Name:
Antibodies for carcino-embryonic antigen (CEA)
Use:
Marketed as a immunohistochemical research reagent useful for the detection and/or study of various cancers
HHS Contribution:
Developed the ATCC cell line designed Col-1
Features:
Does not react with normal colon tissue
Inventors:
J. Schlom
HHS Institute/Agency:
NCI
Licensee:
Zymed Laboratories, Inc.  
Market Launch:
1992
2004
Product Name:
Antibodies to Human Cytochrome P450 2C19
Use:
Selectively and potently inhibits CYP2C19
HHS Contribution:
Discovered agents that bind and inhibit human cytochrome p450 2C19
Features:
Human CYP2C19 Immunogen, raised in mice
Inventors:
H. Gelboin, F. Gonzalez
HHS Institute/Agency:
NCI
Licensee:
Discovery Labware, Inc.  
Market Launch:
2004
1993
Product Name:
Antibody 11/14 against T and B cells
Use:
Reacts with T and B lymphocytes
HHS Contribution:
Established a rat IgG2a anti-mouse and IgM-producing hybridomas in mouse B and T cells
Features:
To stain lymphocytes, dendritic cells and macrophages
Inventors:
G.Laszlo, K. Hathcock, R. Hodes
HHS Institute/Agency:
NCI
Licensee:
BD Biosciences - BD PharMingen  
Market Launch:
1993
1998
Product Name:
Antibody to Human Cytochrome P450-1A2
Use:
These polyclonal antisera inhibit both CYP1A1 and CYP1A2. CYP1A2 is specific for liver
HHS Contribution:
Provided antibodies that bind and inhibit cytochrome P450 1A2.
Features:
The product immunogen is rat CYP1A2.
Inventors:
H. Gelboin
HHS Institute/Agency:
NCI
Licensee:
Becton, Dickinson and Company  
Market Launch:
1998
1998
Product Name:
Antibody to Human Cytochrome P450-2A6
Use:
Potently inhibits CYP2A6, yielding up to 90% of the same human liver microsomal
HHS Contribution:
Discovered monoclonal antibodies and other binding agents to human cytochrome P450 2A6 that have advantageous properties.
Features:
Does not inhibit other human cytochrome p450s
Inventors:
H. Gelboin
HHS Institute/Agency:
NCI
Licensee:
Gentest Corporation  
Market Launch:
1998
2000
Product Name:
Autoimmunity Panel 6
Use:
Detects the presence of specific autoantibodies to help diagnose autoimmune disorders
HHS Contribution:
Developing an effective method to diagnose autoimmune disorders in mammals using recombinant enzymes
Features:
Simultaneously screens for six nuclear antibodies with superior precision and accuracy
Inventors:
N. Raben
HHS Institute/Agency:
NIAMS
Licensee:
GenBio  
Market Launch:
2000
2000
Product Name:
BIOMAX Multi-Blot Kit for Protein Gels
Use:
Simple and rapid method for comprehensive molecular analysis
HHS Contribution:
Method for production of Layered Expression Scans for tissue and cell samples
Features:
Technology Council of Maryland 2002 Bioscience Product of the Year
Inventors:
M. R. Emmert-Buck
HHS Institute/Agency:
NCI
Licensee:
20/20 Gene Systems, Inc.  
Market Launch:
2000
2001
Product Name:
BRACAnalysis®
Use:
Predictive test for risk of breast and ovarian cancer
HHS Contribution:
Isolation and cloning of human breast cancer 1 gene (BRCA 1)
Features:
Current standard of care for identifying hereditary breast and ovarian cancer
Inventors:
M. Skolnic and R. Weisman
HHS Institute/Agency:
NIEHS
Licensee:
Myriad Genetic Laboratories 
Market Launch:
2001
2002
Product Name:
Breast cancer monoclonal antibody
Use:
Markers used for identifying breast cancer cells
HHS Contribution:
Process for Producing Monoclonal Antibodies Reactive with Human Breast Cancer
Features:
Help target uses of Breast cancer susceptibilty genes
Inventors:
J. Schlom, D. Colcher, M. Nuti, P. Hand, F. Austin
HHS Institute/Agency:
NCI
Licensee:
BD Biosciences - BD PharMingen  
Market Launch:
2002
1994
Product Name:
c-erbB-2 (her2-neu) Test
Use:
Used to test for her2-neu oncogene associated with lymph node metastasis
HHS Contribution:
used for diagnostic and therapeutic purposes for her2-neu gene
Features:
Patients with an over-expression of the resulting protein are good candidates for the drug Herceptin
Inventors:
C. King
HHS Institute/Agency:
NCI
Licensee:
Schering AG  
Market Launch:
1994
1998
Product Name:
c-erbB-3 Oncoprotein marker
Use:
Recognizes an epitope in the cytoplasmic domain of the human c-erbB-3 oncoprotein
HHS Contribution:
Sequenced DNA segment encoding a gene the Epidermal Growth Factor Receptor (erbB-3)
Features:
Expression of c-erbB-3 oncoprotein has appeared in chronic pancreatitis, endocrine pancreatic cancer and in tumors of gastro-intestinal tract
Inventors:
M. Kraus, S. Aaronson
HHS Institute/Agency:
NCI
Licensee:
Novocastra Laboratories, Ltd.  
Market Launch:
1998
2005
Product Name:
c-Kit pharmDx™ Control Slides (Mouse)
Use:
c-kit protein expression levels are used for testing quality control of assay kit
HHS Contribution:
Development of P815 murine mast cell line
Features:
c-Kit pharmDx assay kit used in differential diagnosis of gastrointestinal stromal tumors
Inventors:
M. Potter
HHS Institute/Agency:
NCI
Licensee:
Dako Denmark A/S  
Market Launch:
2005
1987
Product Name:
CA72-4 RIA
Use:
Detection kit used to evaluate TAG72 serum levels in patients with gastric and other digestive tract cancers
HHS Contribution:
Developed process for producing monoclonal antibodies reactive with human breast cancer
Features:
Uses two monoclonal antibodies to target TAG-72 antigen
Inventors:
J. Schlom
HHS Institute/Agency:
NCI
Licensee:
Fujirebio Diagnostics, Inc.  
Market Launch:
1987
2000
Product Name:
CAK1 Monoclonal Antibody
Use:
Identify and trace specific cells or molecules in an organism
HHS Contribution:
Developed murine monoclonal antibody K1
Features:
Reacts with epithelial mesothelioma but no with lung adenocarinoma
Inventors:
M. Willingham, K. Chang, I. Pastan
HHS Institute/Agency:
NCI
Licensee:
Signet Laboratories, Inc.  
Market Launch:
2000
2000
Product Name:
Calcineurin Antibodies
Use:
Antibodies used to target a protein phosphatase that plays a role in immunosupression
HHS Contribution:
Developed Calcineurin Antibodies
Features:
Products include polyclonal antibodies designated RACalpha1, RACbeta2, and Hbak as well as purified bovine brain calcineurin
Inventors:
C. Klee, S. Li, C. Saddig, A. Stump
HHS Institute/Agency:
NCI
Licensee:
Upstate Biotechnology, Incorporated  
Market Launch:
2000
1998
Product Name:
Calypte® HIV-1 BED Incidence EIA
Use:
Measures time since HIV-1 infection occurred.
HHS Contribution:
Method of culturing HIV and assays for detection of infection.
Features:
First test of its kind
Inventors:
R. Gallo and L. Montagnier
HHS Institute/Agency:
NCI
Licensee:
Calypte Biomedical Corporation, Inc. 
Market Launch:
1998
1998
Product Name:
Cambridge Biotech HIV-1 Western Blot Kit
Use:
Confirmation of antibodies to HIV-1 in human serum and plasma
HHS Contribution:
Recombinant HIV envelope proteins for detection assays
Features:
First in vitro diagnostic western blot test
Inventors:
T. Papas
HHS Institute/Agency:
NCI
Licensee:
Maxim Biomedical , Inc. 
Market Launch:
1998
1997
Product Name:
CapSure Cap
Use:
Precisely dissects cancerous cells from biopsies for study
HHS Contribution:
Collaborative development of the technology
Features:
First device of its kind
Inventors:
R. Bonner
HHS Institute/Agency:
NICHD
Licensee:
Arcturus Engineering, Inc. 
Market Launch:
1997
2003
Product Name:
Carcinoembryonic Antigen
Use:
Detects early foci of gastric carcinoma and distinguishes pulminary adenocarcinomas from mesothelioma
HHS Contribution:
Provided COL-1 antibodies that keeps CEA binding affinity
Features:
COL-1 clone shows no detectable reactivity with other CEA genes.
Inventors:
J. Schlom
HHS Institute/Agency:
NCI
Licensee:
Biocare Medical, LLC  
Market Launch:
2003
1998
Product Name:
cDNA Libraries/Creator™ SMART™ cDNA Library Construction Kit
Use:
Designed to clone full-length cDNA into a plasmid vector, pDNR-Lib
HHS Contribution:
Created an improved method for the construction of directionally cloned cDNA Libraries from microdissected cells
Features:
The Creator SMART cDNA Library Construction Kit provides enough reagents to construct seven cDNA libraries.
Inventors:
Elise C. Kohn, Michael R. Emmert-Buck
HHS Institute/Agency:
NCI
Licensee:
Clontech Laboratories, Inc  
Market Launch:
1998
1998
Product Name:
Certiva®
Use:
Combined diphtheria, tetanus and acellular pertussis vaccine for use in infants and children
HHS Contribution:
Culturing whooping cough bacterium and inactivating its toxin for immunization
Features:
Reduced side-effects from vaccine formulation
Inventors:
R. Sekura
HHS Institute/Agency:
NICHD
Licensee:
Baxter International, Inc. 
Market Launch:
1998
2007
Product Name:
Cervarix®
Use:
Vaccine for human papilloma virus (HPV) to protect from cancers
HHS Contribution:
Non-infectious HPV-like particles for immunization
Features:
First EU approved vaccine against cervical cancer and genital warts
Inventors:
D. Lowy
HHS Institute/Agency:
NCI
Licensee:
GlaxoSmithKline 
Market Launch:
2007
1991
Product Name:
CHAPS
Use:
Useful for solubilizing animal cell membrane proteins
HHS Contribution:
Development of a stable chemical for disolving cell membrane proteins
Features:
The most popular reagent used in labs to dissolve cell membrane proteins
Inventors:
L. Hjelmeland
HHS Institute/Agency:
NICHD
Licensee:
Sigma-Aldrich 
Market Launch:
1991
2006
Product Name:
Click-iT™ O-GlcNAc Enzymatic Labeling System
Use:
It provides a highly sensitive and efficient method for the in-vitro modification of O-GlcNAc modified proteins
HHS Contribution:
Discovered that the enzymatic activity of (1,4)-galactosyltransferase can be altered so that the enzyme can make chemical bonds more easily.
Features:
Labeling and detection can be completed in less than 24 hours.
Inventors:
P. Qasba, B. Ramakrishnan
HHS Institute/Agency:
NCI
Licensee:
Invitrogen Corporation  
Market Launch:
2006
2001
Product Name:
Clones AD1, BC4, AA4
Use:
Biological materials used in research and treatment development for allergies, cancer, and parasites
HHS Contribution:
Producing the antibodies directed at certain cells and other antibody fractions of rats
Features:
Controllable and reproducible clones suited for flow cytometry, immunoprecipitation, and frozen section procedures
Inventors:
R. Sirangania
HHS Institute/Agency:
NIDCR
Licensee:
BD PharMingen  
Market Launch:
2001
2002
Product Name:
Cultrex® Basement Membrane Extract
Use:
Ideal for cell invasion, tissue regrowth, and cancer development studies
HHS Contribution:
Extracting and preparing a biologically active membrane complex from mouse cancer cells
Features:
Tested and cleared for 31 pathogens that include viruses, bacteria, and mycoplasma
Inventors:
H. Kleinman
HHS Institute/Agency:
NIDCR
Licensee:
Trevigen, Inc.  
Market Launch:
2002
2005
Product Name:
Cultrex® DIVAA™ Angiogenesis Activation Assay Kit
Use:
Designed for assessing angiogenesis activation
HHS Contribution:
Discovered a method of performing an in vivo angiogenesis assay which involves the use of a matrix material
Features:
The Kit controls the site for angiogenesis, increasing reproducibility, and conserving test compounds
Inventors:
G. Martin
HHS Institute/Agency:
NCI
Licensee:
Trevigen, Inc.  
Market Launch:
2005
2005
Product Name:
Cultrex® DIVAA™ Angiogenesis Assay Kit
Use:
Designed for assessing angiogenesis activation
HHS Contribution:
Discovered a method of performing an in vivo angiogenesis assay which involves the use of a matrix material
Features:
The Kit controls the site for angiogenesis, increasing reproducibility, and conserving test compounds
Inventors:
G. Martin
HHS Institute/Agency:
NCI
Licensee:
Trevigen, Inc.  
Market Launch:
2005
2005
Product Name:
Cultrex® DIVAA™ Angiogenesis Starter Kit
Use:
Angioreactor optimizes sensitivity and provides a more controlled experiment
HHS Contribution:
Discovered a method of performing an in vivo angiogenesis assay which involves the use of a matrix material
Features:
The Kit controls the site for angiogenesis, increasing reproducibility, and conserving test compounds
Inventors:
G. Martin
HHS Institute/Agency:
NCI
Licensee:
Trevigen, Inc.  
Market Launch:
2005
2005
Product Name:
Cultrex® DIVAA™ Inhibition Kit
Use:
Designed for assessing angiogenesis inhibition
HHS Contribution:
Discovered a method of performing an in vivo angiogenesis assay which involves the use of a matrix material
Features:
The Kit controls the site for angiogenesis, increasing reproducibility, and conserving test compounds
Inventors:
G. Martin
HHS Institute/Agency:
NCI
Licensee:
Trevigen, Inc.  
Market Launch:
2005
1999
Product Name:
CYP2A6 Antibody
Use:
Inhibits the CYP2A6 activity
HHS Contribution:
Discovered agents that bind and inhibit human cytochrome p450 2A6
Features:
Does not cross react with other human p450 isoforms
Inventors:
H. Gelboin
HHS Institute/Agency:
NCI
Licensee:
PanVera LLC  
Market Launch:
1999
1989
Product Name:
Detect HIV/Select HIV Kit
Use:
Screens for HIV virus
HHS Contribution:
Detected antibodies to HIV in serum of patients with AIDS and pre-AIDS conditions, and consequently, linked the HIV virus to AIDS
Features:
Faster results than ELISA Kit and this test can be performed anywhere, including mobile screening units
Inventors:
R. Gallo and L. Montagnier
HHS Institute/Agency:
NCI
Licensee:
Adaltis  
Market Launch:
1989
1992
Product Name:
Diagnostic Assays for Helicobacter (PCR tests)
Use:
Detects the presence of bacteria or viruses in different organisms
HHS Contribution:
Isolated Helicobacter hepaticus nucleic acid and provided a specific antigen.
Features:
Tests are conducted in different rooms to prevent cross contamination
Inventors:
J. Ward
HHS Institute/Agency:
NCI
Licensee:
Anmed/Biosafe, Inc.  
Market Launch:
1992
2005
Product Name:
Didanosine
Use:
Treatment of HIV infection with dideoxyinosine (generic equivalent for Videx® EC)
HHS Contribution:
Discovery and early drug development of dideoxyinosine (ddI)
Features:
Generic version of 2nd FDA approved AIDS drug
Inventors:
R. Yarchoan and H. Mitsuya
HHS Institute/Agency:
NCI
Licensee:
Barr Laboratories, Inc. 
Market Launch:
2005
1995
Product Name:
Diethylenetriamine (Nitric Oxide Adduct)
Use:
Long-acting nitric oxide donor
HHS Contribution:
Discovered complexes of nitric oxide and polyamines that are potentially useful in treating cardiovascular disorders
Features:
Controlled, long-term release of nitric oxide under physiologic conditions
Inventors:
L. Keefer
HHS Institute/Agency:
NCI
Licensee:
Sigma-R.B.I.  
Market Launch:
1995
1994
Product Name:
Diethylenetriamine NONOate (Nitric Oxide Donors)
Use:
Research tool/reagent for nonhuman investigations
HHS Contribution:
Synthesized nitric oxide donor useful for localizing antithrombotic, vasodilatory, and other nitric oxide-mediated activities
Features:
It spontaneously dissociates in a pH- dependent
Inventors:
J. Saavedra, M. Akamatsu, L. Keefer, P. Roller
HHS Institute/Agency:
NCI
Licensee:
Cayman Chemical Company  
Market Launch:
1994
2004
Product Name:
Diethylenetriamine pentaacetate
Use:
Material for the treatment for contamination of radioactive material
HHS Contribution:
Created methods utilizing the bifunctional cyclohexyl DPTA ligands
Features:
Also prevents the mixture of other ingredients in a product
Inventors:
O. Gansow
HHS Institute/Agency:
NCI
Licensee:
Macrocyclics, Inc.  
Market Launch:
2004
1996
Product Name:
Diffusion Tensor Imaging
Use:
MRI technique to help diagnose problems in the brain
HHS Contribution:
A method and system for measuring the effective diffusion tensor for spin labeled particles, and generating images
Features:
Useful in measuring the effective diffusion tensor for spin labeled particles and for generating images.
Inventors:
P. Basser, J. Mattiello, D. LeBihan
HHS Institute/Agency:
NCI
Licensee:
Covance Research Products, Inc.  
Market Launch:
1996
2005
Product Name:
Diffusion tensor MRI
Use:
Mapping white matter in brain using MRI
HHS Contribution:
Method of MRI using water movement along parallel neurons.
Features:
Unique ability to display live tissues non-invasively without injecting the patient
Inventors:
P. Basser and C. Pierpaoli
HHS Institute/Agency:
NINDS
Licensee:
Siemens Aktiengesellschaft 
Market Launch:
2005
2002
Product Name:
DPD Exon-14 Skipping mutation test
Use:
To identify Exon 14-Skipping Mutation in the DPD-gene for cancer patients.
HHS Contribution:
Devised methods and compositions useful for detecting deficiencies in dihydropyrimidine dehydrogenase (DPD) levels in humans
Features:
Could help substantially reduce health care expenses
Inventors:
F. Gonzales P. Fernandez-Salguero
HHS Institute/Agency:
NCI
Licensee:
Oncoscreen GmbH  
Market Launch:
2002
2005
Product Name:
DUALmembrane starter kits
Use:
Screen full-length integral membrane proteins in vivo
HHS Contribution:
Developed efficient directional genetic cloning system
Features:
Has a variety of easy-to-use kits to choose from
Inventors:
T. Miki, S. Aaronson
HHS Institute/Agency:
NCI
Licensee:
DUALSYSTEMS Biotech, AG  
Market Launch:
2005
1996
Product Name:
ECM Gel
Use:
This gel is used in research as a base for culturing cells
HHS Contribution:
Extracting and preparing a biologically active membrane complex from mouse cancer cells
Features:
Promotes differentiation and growth of cells in three-dimensional culture systems
Inventors:
H. Kleinman and G. Martin
HHS Institute/Agency:
NIDCR
Licensee:
Sigma Chemical Corporation  
Market Launch:
1996
1994
Product Name:
ERBB-3 Receptor
Use:
Localization, but with limited information, of nuclear ERBB-3 receptor protein
HHS Contribution:
Previous research prompted the designation of the new gene as erbB-3
Features:
Small inhibitory RNA to ERBB3 or AKT is showing promise as a therapeutic approach to treatment of lung adenocarcinoma.
Inventors:
M. Kraus, S. Aaronson
HHS Institute/Agency:
NCI
Licensee:
Oncogene Sciences, Inc.  
Market Launch:
1994
2001
Product Name:
Familial Mediterranean Fever (FMF) GenotypR™
Use:
Blood test to screen individuals with the gene for Familial Mediterranean Fever
HHS Contribution:
Identifying the gene on chromosome 16 responsible for causing Familial Mediterranean Fever
Features:
Earlier and more accurate diagnoses by detecting almost 75% of the genetic mutations associated with FMF
Inventors:
D. Kastner et al
HHS Institute/Agency:
NIAMS
Licensee:
Specialty Labs, Inc.  
Market Launch:
2001
2000
Product Name:
Familial Mediterranean Fever Testing
Use:
To screen affected individuals and carriers of FMF using cheek swabs, blood samples, or body fluid
HHS Contribution:
Identifying the gene on chromosome 16 responsible for causing Familial Mediterranean Fever
Features:
Earlier treatment participation made possible by analyzing key areas of the gene and detecting mutations in the FMF gene
Inventors:
D. Kastner et al
HHS Institute/Agency:
NIAMS
Licensee:
GeneDx, Inc.  
Market Launch:
2000
1996
Product Name:
Fibronectin Fragment
Use:
Mediate cell adhesion and promote neurite outgrowth
HHS Contribution:
Obtained evidence for significant direct effects of TSP1 on T cell responses that are involved in anti-tumor immunity
Features:
Has been located in several other heparin/heparan sulfate-binding proteins and may represent a potential binding motif for sulfated polyanions
Inventors:
D. Roberts
HHS Institute/Agency:
NCI
Licensee:
Bachem California  
Market Launch:
1996
1991
Product Name:
Fludara®
Use:
Treatment of chronic lymphocytic leukemia (CLL) for patients who did not respond to alkylating agents
HHS Contribution:
Synthesis and use of fludarabine for cancer
Features:
First treatment in a new class of highly effective chemotherapy agents (the purine analogues) for chronic lymphocytic leukemia
Inventors:
J. Montgomery
HHS Institute/Agency:
NCI
Licensee:
Schering AG  
Market Launch:
1991
2004
Product Name:
Fluorescent Pteridine-based Nucleoside analog probes
Use:
Used for various application for the study of DNA interactions
HHS Contribution:
Developed Fluorescent Pteridine Nucleotide Analogs
Features:
Provides opportunities for monitoring subtle changes in DNA structure
Inventors:
M. Hawkins, F. Balis, W. Pfleiderer
HHS Institute/Agency:
NCI
Licensee:
Fidelity Systems, Inc.  
Market Launch:
2004
1994
Product Name:
Fluorognost™ HIV-1 IFA
Use:
Detects antibodies to HIV-1 in human serum or plasma
HHS Contribution:
More sensitive and more specific than Western blotting techniques; as a result, it is sometimes used as an additional test
Features:
Detected antibodies to HIV in serum of patients with AIDS and pre-AIDS conditions, and consequently linked the HIV virus to AIDS
Inventors:
R. Gallo, L. Montganier
HHS Institute/Agency:
NCI
Licensee:
Waldheim Pharmazuetika GmbH  
Market Launch:
1994
2006
Product Name:
Gardasil®
Use:
Vaccine for human papilloma virus (HPV) to protect from cancers
HHS Contribution:
Non-infectious HPV-like particles for immunization
Features:
First FDA approved vaccine against cervical cancer and genital warts
Inventors:
D. Lowy
HHS Institute/Agency:
NCI
Licensee:
Merck Co. Inc. 
Market Launch:
2006
2002
Product Name:
GeneSeq HIV
Use:
Used to diagnose patients that have drug resistant HIV.
HHS Contribution:
Propagation of HIV in the lab and HIV proteases used for drug development.
Features:
Extensive gene database of HIV strains associated with drug resistance
Inventors:
A. Babson, A., S. Oroszlan, L. Montagnier, M. Eiden, E Berger, and C. Combadiere
HHS Institute/Agency:
NIAID
Licensee:
Monogram Biosciences 
Market Launch:
2002
1998
Product Name:
Genetic Systems HIV-1 Western Blot
Use:
Used to confirm HIV infections.
HHS Contribution:
Propagation of HIV in the lab and HIV proteases used for drug development.
Features:
Offers same-day results for faster turn around and is suited for using dried blood
Inventors:
L. Montagnier and R. Gallo
HHS Institute/Agency:
NCI
Licensee:
Bio-Rad Laboratories, Inc 
Market Launch:
1998
1993
Product Name:
GL-1 antibody against T and B cells
Use:
Reacts with T and B lymphocytes
HHS Contribution:
Established a rat IgG2a anti-mouse and IgM-producing hybridomas in mouse B and T cells
Features:
To stain lymphocytes, dendritic cells and macrophages
Inventors:
G.Laszlo, K. Hathcock, R. Hodes
HHS Institute/Agency:
NCI
Licensee:
BD Biosciences - BD PharMingen  
Market Launch:
1993
1993
Product Name:
GL-7 antibody against T and B cells
Use:
Reacts with T and B lymphocytes
HHS Contribution:
Established a rat IgG2a anti-mouse and IgM-producing hybridomas in mouse B and T cells
Features:
To stain lymphocytes, dendritic cells and macrophages
Inventors:
G.Laszlo, K. Hathcock, R. Hodes
HHS Institute/Agency:
NCI
Licensee:
BD Biosciences - BD PharMingen  
Market Launch:
1993
1997
Product Name:
Growth Arrest and DNA Damage-45
Use:
Gadd45 expression has been shown to be dependent on the tumor suppressor and p53 transcription factor
HHS Contribution:
Identified a critical role Gadd45a that protects the skin against cancer-causing damage from the sun's rays.
Features:
GADD45 is the only known x-ray responsive gene whose induction is not mediated by PKC
Inventors:
J. Hildesheim, M Anver, W Alvord, M Hollander, A Fornace
HHS Institute/Agency:
NCI
Licensee:
Zymed Laboratories, Inc.  
Market Launch:
1997
2006
Product Name:
Havrix®
Use:
Vaccine against Hepatitis A
HHS Contribution:
Propagation of Hepatitis A virus strain HM-175 in cell culture rather than animal hosts
Features:
Protects against a common virus acquired during travel
Inventors:
R. Daemer et al.
HHS Institute/Agency:
NIAID
Licensee:
SmithKline Beecham 
Market Launch:
2006
1995
Product Name:
Heat Shock Factor
Use:
HSF regulates the expression of Heat Shock Proteins
HHS Contribution:
Discovered that presence of HSF in the nucleus of a cell can be detected with specific anti-HSF antibody reagents.
Features:
A set of complete antibodies to identify the cancer cause related stress proteins including Hsp 27, Hsp 60, Hsp 70 and Hsp 90 for in vitro use
Inventors:
C. Wu
HHS Institute/Agency:
NCI
Licensee:
Stressgen Bioreagents Limited Partnership  
Market Launch:
1995
1995
Product Name:
Heat Shock Factor 1
Use:
The antibody detects heat shock factor 1 from human, mouse and rat tissues and cells.
HHS Contribution:
Discovered in vitro detection of HSF-1 in tissue culture cells
Features:
Has been successfully used in Western blot, immunoprecipitation, ELISA, and gel super shift protocols.
Inventors:
C Wu
HHS Institute/Agency:
NCI
Licensee:
Affinity BioReagents, Inc.  
Market Launch:
1995
1999
Product Name:
Heregulin-β3 (growth factor)
Use:
Used to aid the growth of certain types of cells
HHS Contribution:
Developed a method for producing Human Heregulin Growth Factor Beta
Features:
Routinely evaluated by Receptor Activation Analysis
Inventors:
J. Pierce, M. Alimandi, L. Wang
HHS Institute/Agency:
NCI
Licensee:
Upstate Biotechnology, Incorporated  
Market Launch:
1999
1995
Product Name:
HHV-6 Antibodies
Use:
Identify and trace specific cells or molecules in an organism
HHS Contribution:
Isolated Human B Lymphotropic Virus (HHV-6)
Features:
Can provide serological evidence of previous HHV-6 infection
Inventors:
S. Salahuddin, D. Ablashi, R. Gallo, S. Josephs, F. Saxinger, F. Wong-Staal
HHS Institute/Agency:
NCI
Licensee:
Advanced Biotechnologies, Inc.  
Market Launch:
1995
2000
Product Name:
HIV 1 /2 STAT-PAK® Dipstick Assay
Use:
Diagnostic tests for the rapid detection of antibodies to HIV-1 and HIV-2
HHS Contribution:
Detected antibodies to HIV in serum of patients with AIDS and pre-AIDS conditions, and consequently linked the HIV virus to AIDS
Features:
Delivers fast, accurate results to help clinical decision-making
Inventors:
R. Gallo
HHS Institute/Agency:
NCI
Licensee:
Chembio Diagnostic Systems, Inc.  
Market Launch:
2000
2000
Product Name:
HIV 8E5 (cell line)
Use:
Suited for investigations of HIV recombination in tissue culture
HHS Contribution:
Cell Line Producing AIDS Viral Antigens without Producing Infectious Viral Particles
Features:
Contain a single copy of a defective HIV provirus with a mutation
Inventors:
T. Folks, M. Martin D. Powell
HHS Institute/Agency:
NCI
Licensee:
BBI-Biotech Research Laboratories, Inc.  
Market Launch:
2000
1995
Product Name:
HIV assay
Use:
Detecting the presence of antibodies to the retrovirus associated with AIDS
HHS Contribution:
Developed terrological detection of antibodies to HTLV-III and method of production of retroviruses (HTLV-III)
Features:
Produce results that are highly accurate, reliable, and appropriate to protect the blood supply or assist in the diagnosis of HIV infection
Inventors:
R. Gallo, M. Popovic, M. Sarngadharan
HHS Institute/Agency:
NCI
Licensee:
SmithKline Beecham Pharmaceuticals  
Market Launch:
1995
2006
Product Name:
HIV lysate
Use:
Test kit used for the detection of HIV-1 in serum, plasma, or urine
HHS Contribution:
Developed a method of testing human blood for the presence of antibodies to the HIV virus using the envelope protein.
Features:
Can also help purify viral proteins
Inventors:
R. Gallo and R. Crowl
HHS Institute/Agency:
NCI
Licensee:
Maxim Biomedical Inc.  
Market Launch:
2006
1998
Product Name:
HIV-1 lysate
Use:
Detects HIV-1 antibodies
HHS Contribution:
Serological detection of antibodies to HTLV-III in sera of patients with AIDS and pre-AIDS conditions
Features:
Can also help purify viral proteins
Inventors:
R. Gallo, M Popovic, M. Sarngadharan
HHS Institute/Agency:
NCI
Licensee:
Beacon Diagnostics, Inc.  
Market Launch:
1998
1996
Product Name:
HIV-1 p24 antigen assay
Use:
Diagnostic test for HIV
HHS Contribution:
Cell lines producing non-infectious HIV antigens
Features:
Can detect HIV only 19 days after initial exposure, six days earlier than other tests.
Inventors:
T. Folks ET al.
HHS Institute/Agency:
NIAID
Licensee:
Coulter Corporation 
Market Launch:
1996
1992
Product Name:
HIV-1 p24 ELISA KIT
Use:
Diagnostic kit for measurement of p24 protein in serum or plasma
HHS Contribution:
Produced HIV-1 in cell culture and developed methods of serological detection of antibodies to HIV-1.
Features:
Reliable and easy to use
Inventors:
M. Sargandharan, J. Medabalimi, S. Oroszlan, L. Montagnier and R. Crowl
HHS Institute/Agency:
NCI
Licensee:
Trinity Biotech, Plc  
Market Launch:
1992
1996
Product Name:
HIV-1 p24 ELISA kit
Use:
Diagnostic immunoassay kit for measurement of p24 protein in serum or plasma
HHS Contribution:
Produced monoclonal antibodies to HIV virus p24 proteins
Features:
Reliable and easy to use
Inventors:
M. Sarngadharan, F. di Marzo Veronese, R. Gallo
HHS Institute/Agency:
NCI
Licensee:
Coulter Corporation  
Market Launch:
1996
2000
Product Name:
HIV-1 Protease
Use:
Research reagent employed in developing treatments for Human Immunodeficiency Virus
HHS Contribution:
Utilizing recombinant methods to produce highly purified HIV-1 protease in bacteria
Features:
One of the most important targets for developing an anti-HIV-1 drug
Inventors:
S. Stahl and P. Wingfield
HHS Institute/Agency:
NIAMS
Licensee:
Veritas, Incorporated  
Market Launch:
2000
1993
Product Name:
HIV-1/2
Use:
Immunoassay for simultaneous detection of HIV p24 antigen and HIV 1/2 antibodies
HHS Contribution:
Co-discovered Human Immunodeficiency Virus 9HIV)
Features:
Easy-to-use and reliable
Inventors:
R. Gallo, et al
HHS Institute/Agency:
NCI
Licensee:
Abbott Laboratories, Inc.  
Market Launch:
1993
1992
Product Name:
Hivid®
Use:
Used in combination with antiretroviral agents for the treatment of HIV infection
HHS Contribution:
Didieoxycytidine (ddC) as inhibitor of HIV reverse-transcriptase
Features:
Third antiretroviral approved by FDA for HIV/AIDS
Inventors:
H. Mitsuya
HHS Institute/Agency:
NCI
Licensee:
Roche Laboratories, Inc. 
Market Launch:
1992
1991
Product Name:
HTLV Blot 2.4
Use:
Confirmatory test that can detect both HTLV-I and HTLV-II viruses
HHS Contribution:
Produced HTLV-1 envelope proteins in bacteria
Features:
Coated with a monoclonal antibody specific for the p24
Inventors:
S. Broder, S. Matsushita, M.Robert-Guroff
HHS Institute/Agency:
NCI
Licensee:
Genelabs  
Market Launch:
1991
1993
Product Name:
HTLV III ELISA
Use:
Screens for the presence of antibodies to HIV-1 and HIV-2.
HHS Contribution:
Detected antibodies to HIV in serum of patients with AIDS and pre-AIDS conditions, and consequently, linked the HIV virus to AIDS
Features:
Inventors:
R. Gallo, L. Montagnier
HHS Institute/Agency:
NCI
Licensee:
Genelabs  
Market Launch:
1993
1993
Product Name:
HTLV-I Tests
Use:
Screens for HTLV-1 virus
HHS Contribution:
Produced HTLV-1 envelope proteins in bacteria
Features:
Backed by world-class service and strong local support
Inventors:
S. Broder, S. Matsushita, M.Robert-Guroff
HHS Institute/Agency:
NCI
Licensee:
Roche Laboratories, Inc.  
Market Launch:
1993
2000
Product Name:
HTLV-III antibody serological detection
Use:
Detection method used in AIDS tests
HHS Contribution:
Detected antibodies to HIV in serum of patients with AIDS and pre-AIDS conditions, and consequently, linked the HIV virus to AIDS
Features:
Coated with HTLV-III and ELISA materials
Inventors:
R. Gallo, L. Montangier
HHS Institute/Agency:
NCI
Licensee:
Intracel Corporation  
Market Launch:
2000
1994
Product Name:
HTLV-III antibody serological detection
Use:
Detection method used in AIDS tests
HHS Contribution:
Detected antibodies to HIV in serum of patients with AIDS and pre-AIDS conditions
Features:
Inventors:
R. Gallo, L. Montagnier, and R. Crowl
HHS Institute/Agency:
NCI
Licensee:
Roche Laboratories, Inc.  
Market Launch:
1994
1993
Product Name:
HTLV-III antibody serological detection
Use:
Detection method used in AIDS tests
HHS Contribution:
Detected antibodies to HIV in serum of patients with AIDS and pre-AIDS conditions
Features:
Coated with HTLV-III for ELISA Detection
Inventors:
R. Gallo
HHS Institute/Agency:
NCI
Licensee:
Pharmacia-Upjohn Company  
Market Launch:
1993
1998
Product Name:
Human (hu-8845) antibody
Use:
Identify PLK enzymes in vitro
HHS Contribution:
Developed hu-1882 PLK-peptide
Features:
Specific for human PLK identification
Inventors:
D. Ferris
HHS Institute/Agency:
NCI
Licensee:
Upstate Biotechnology, Incorporated  
Market Launch:
1998
1999
Product Name:
Human Cytochrome P450 antibodies
Use:
Selectively and potently inhibits the human cytochrome p450
HHS Contribution:
mAb to human cytochrome P450, 2C8, 2C9, 2C18, and 2C19
Features:
No detection of cross reactions with other human cytochrome p450s.
Inventors:
H. Gelboin
HHS Institute/Agency:
NCI
Licensee:
Becton, Dickinson and Company  
Market Launch:
1999
1997
Product Name:
Human IL-8
Use:
Circulating human IL-8 might be a useful, clinically relevant circulating tumor protein marker due to its positive correlation with multiple physiologic variables associated with lung cancer progression
HHS Contribution:
Discovered nucleic acids encoding a novel neutrophil chemotactic factor IL-8.
Features:
There are Elisa Kits, Anti-Human Il-8, and Recombinants from which to choose from.
Inventors:
K. Matushima
HHS Institute/Agency:
NCI
Licensee:
PeproTech, Inc.  
Market Launch:
1997
1996
Product Name:
Human Immunodeficiency Virus (HIV), p24
Use:
Reacts with and labels cells expressing p24
HHS Contribution:
Disclosed antibodies that bind very specifically to proteins associated with the HTLV-III virus
Features:
Helps study HIV antigen tissue sections.
Inventors:
R. Gallo, F. Veronese, M. Samgadharan
HHS Institute/Agency:
NCI
Licensee:
Dako Denmark A/S  
Market Launch:
1996
1992
Product Name:
Human interleukin 1 beta (IL – 1β) antibody
Use:
Identify and trace specific cells or molecules in an organism
HHS Contribution:
Developed 3DZ cell line producing monoclonal antibody to IL-1 beta
Features:
IL-1 Beta is an important mediator of the inflammatory response
Inventors:
J. Oppenheim
HHS Institute/Agency:
NCI
Licensee:
Upstate Biotechnology, Incorporated  
Market Launch:
1992
1994
Product Name:
Human NM23 Protein & Antibodies
Use:
Used to detect NM23 in human tumors to predict the malignancy potential of such tumors
HHS Contribution:
Human NM23 DNA, protein and antibodies
Features:
NM23 is now more widely studied because of its role in metastasis suppression and oncogenesis
Inventors:
C. King, P. Steeg, L. Liotta,
HHS Institute/Agency:
NCI
Licensee:
Oncogene Sciences, Inc.  
Market Launch:
1994
1995
Product Name:
Human NM23 Proteins & Antibodies
Use:
Expression of the protein correlates with metastatic potential of tumors
HHS Contribution:
Production and Use of Human NM23 Protein and Antibodies
Features:
Inhibits differentiation, interacts with GTP-binding (GAP) proteins, autophosphorylates serine residues, and binds to DNA
Inventors:
C. King, L. Liotta, P. Steeg
HHS Institute/Agency:
NCI
Licensee:
BD Biosciences - BD PharMingen  
Market Launch:
1995
2002
Product Name:
Human p53 PTM antibodies
Use:
Research tool for studying human p53 protein functions
HHS Contribution:
Developed unpurified rabbit antisera against acetyl-human p53 (Lys 382)
Features:
Human p53 is post-translationally modified (PTM) on at least 18 sites in response to different stresses
Inventors:
B. Appella, Y. Higashimoto
HHS Institute/Agency:
NCI
Licensee:
Trevigen, Inc.  
Market Launch:
2002
1998
Product Name:
Human Thymidylate Synthase Antibody
Use:
Specifically reacts to human thymidylate synthase
HHS Contribution:
Developed a hybridoma that produces a monoclonal antibody specific to thymidylate synthase
Features:
Overexpression of Thymidylate Synthesis usually leads to a shorter survival time of certain types of tumors
Inventors:
C. Allegra, B. Chabner,
HHS Institute/Agency:
NCI
Licensee:
Oncotech Incorporated  
Market Launch:
1998
2003
Product Name:
Human Thymidylate Synthase Antibody
Use:
Used for de novo synthesis of DNA and reacts specifically with human Thymidylate Synthase
HHS Contribution:
Developed the hybridoma that produces a monoclonal antibody specific for hymidylate synthase
Features:
Overexpression of Thymidylate Synthase usually leads to a shorter survival time of certain types of tumors
Inventors:
C. Liang, B. Chabner, C. Allegra, P. Johnston
HHS Institute/Agency:
NCI
Licensee:
QED Bioscience, Inc.  
Market Launch:
2003
1994
Product Name:
Hybridoma clone 2G9C3 kit
Use:
In vivo or in vitro use for detecting or treating human cancer
HHS Contribution:
Developed hybridoma clone 2G9C3
Features:
Engineered to produce a desired antibody in large anounts
Inventors:
L. Varesio, S. Giardina, D. Longo
HHS Institute/Agency:
NCI
Licensee:
Bayer Corporation  
Market Launch:
1994
1993
Product Name:
Hybridoma MAb13
Use:
Applications in research, diagnostics, and treatment due to its effects on cell attachment, spreading, and migration
HHS Contribution:
Producing the actual cells by fusing spleen cells and cancer cells
Features:
Antibodies specifically target human α5 β1 integrins which play a significant role in wound healing and tumor growth
Inventors:
K. Yamada
HHS Institute/Agency:
NIDCR
Licensee:
Becton, Dickinson and Company  
Market Launch:
1993
1994
Product Name:
Hybridoma MAb16
Use:
Applications in research, diagnostics, and treatment due to its effects on cell attachment, spreading, and migration
HHS Contribution:
Producing the actual cells by fusing spleen cells and cancer cells
Features:
Antibodies specifically target human α5 β1 integrins which play a significant role in wound healing and tumor growth
Inventors:
K. Yamada
HHS Institute/Agency:
NIDCR
Licensee:
Becton, Dickinson and Company  
Market Launch:
1994
1997
Product Name:
IL-8 Protein Kit
Use:
Detection of individual cells secreting specific cytokines
HHS Contribution:
Determined solution structure of interleukin-8 (IL-8/NAP-1)
Features:
Shown to down-modulate inflammatory activity
Inventors:
M. Yamada and K. Matsushima
HHS Institute/Agency:
NCI
Licensee:
Research and Diagnostic Systems, Inc.  
Market Launch:
1997
1996
Product Name:
Inbred miniature swine SLA haplotypes
Use:
Provides a method of inducing tolerance in a recipient mammal of a first species to a graft from a donor mammal of a second species
HHS Contribution:
Produced homozygous and recombinant miniature swine
Features:
Used as a research tool in a variety of medical and pharmacological applications
Inventors:
D. Sachs
HHS Institute/Agency:
NCI
Licensee:
Charles River Laboratories  
Market Launch:
1996
1997
Product Name:
INNO-LIA™ HTLV I/II Score
Use:
Diagnostic test that can differentiate between HIV-1 and HIV-2
HHS Contribution:
Detected antibodies to HIV in serum of patients with AIDS and pre-AIDS conditions, and linked the HIV virus to AIDS
Features:
Incorporates recombinant proteins and synthetic peptides from HTLV I and II
Inventors:
R. Gallo, L. Montagnier
HHS Institute/Agency:
NCI
Licensee:
Innogenetics, N.V.  
Market Launch:
1997
2001
Product Name:
Interleukin-2 Antibody
Use:
Used for the detection of IL-2 of human origin
HHS Contribution:
Disclosed a sandwich method and a kit for assaying interleukin-2 receptor (IL-2R) in a sample.
Features:
Antibodies raised against full length recombinant IL-2 of rat/human/sheep origin
Inventors:
R. Yarchoan, W. Leonard, D. Nelson,
HHS Institute/Agency:
NCI
Licensee:
Santa Cruz Biotechnology, Inc.  
Market Launch:
2001
1999
Product Name:
Interleukin-2 Receptor Antibody
Use:
Antibodies against CD25 for potential use as an immunodirected therapy to selectively attack (kill) CD25 expressing cells
HHS Contribution:
Discloses a sandwich method and a kit for assaying interleukin-2 receptor (IL-2R) in a sample.
Features:
Recognizes epitope B of the IL-2 alpha receptor of about 55 kd (1,6)
Inventors:
R. Yarchoan, W. Leonard, D. Nelson
HHS Institute/Agency:
NCI
Licensee:
Ancell Corporation  
Market Launch:
1999
1997
Product Name:
Interleukin-8 Protein and Antibodies
Use:
Antibody reacts with the 72 and 77 amino acid forms of human IL-8
HHS Contribution:
Previously determined solution structure of interleukin-8 (IL-8/NAP-1)
Features:
No cross-reactivity with any other cytokines that were tested
Inventors:
M. Yamada and K. Matsushima
HHS Institute/Agency:
NCI
Licensee:
BD Biosciences - BD PharMingen  
Market Launch:
1997
2005
Product Name:
iTAG MHC Mart 1 Tetramer Technology
Use:
iTAg reagents allow for measurement against one specific peptide
HHS Contribution:
Discovered a nucleic acid sequence encoding a melanoma antigen recognized by T lymphocytes, designated MART-1.
Features:
Suitable for basic and clinical research in a number of applications including drug / vaccine development.
Inventors:
S. Rosenberg, Y. Kawakami
HHS Institute/Agency:
NCI
Licensee:
Beckman Coulter, Inc.  
Market Launch:
2005
2001
Product Name:
iTag™ MHC Tetramers
Use:
Used for the ex vivo quantification of cellular immune response
HHS Contribution:
Sequenced various melanoma peptides
Features:
MHC Tetramer technology has been used to accurately monitor CD8+ T cell responses (viruses, parasitic infections, cancers)
Inventors:
Y. Kawakami, S. Rosenberg
HHS Institute/Agency:
NCI
Licensee:
Beckman Coulter, Inc.  
Market Launch:
2001
2002
Product Name:
K1 antibodies
Use:
Used as a research reagent to enhance the understanding of certain cancers, such as, ovarian, esophageal and cervical carcinomas
HHS Contribution:
Developed monoclonal antibody useful for the diagnosis of cancer
Features:
Can be a diagnostic for the detection of mesothelin positive tumors
Inventors:
M. Willingham, K. Chang, I. Pastan
HHS Institute/Agency:
NCI
Licensee:
Zymed Laboratories, Inc.  
Market Launch:
2002
2004
Product Name:
Kepivance®
Use:
Treatment of severe mouth sores that afflict hematologic cancer patients who receive myelotoxic therapy
HHS Contribution:
Characterized the effects of the chemical palifermin which is a human keratinocyte growth factor (KGF)
Features:
Improves the most debilitating side effect cited for blood cancer therapy
Inventors:
J. Rubin
HHS Institute/Agency:
NCI
Licensee:
Amgen, Inc. 
Market Launch:
2004
2001
Product Name:
Keratinocyte Growth Factor & KGF Antibodies
Use:
Identifies keratinocyte of growth factors, i.e. embryonic development, cell growth, morphogenesis, tumor growth,and invasion
HHS Contribution:
Discovered recombinant DNA technology to produce the human keratinocyte growth factor (KGF) pure proteins
Features:
the gene is connected with morphogenesis of epithelium and early lung organogenesis
Inventors:
J. Rubin
HHS Institute/Agency:
NCI
Licensee:
PeproTech, Inc.  
Market Launch:
2001
1998
Product Name:
LambdaSelect-cII™ Mutation Assay Kit
Use:
Detect in vivo mutations of E. coli phage lambda 1
HHS Contribution:
A novel assay for the detection of mutations in the lambda transgenes
Features:
the number of plaques that need to be screened is reduced
Inventors:
J L Jakubczak, G Merlino, J E French, W J Muller, B Paul, S Adhya, and S Garges
HHS Institute/Agency:
NCI
Licensee:
Stratagene California  
Market Launch:
1998
1997
Product Name:
Long Terminal Repeat Vector
Use:
Uses LTR vectors to screen for a protein of interest.
HHS Contribution:
Describes retrovirus LTR vectors and model sytems involving LTR vectors derived from Maloney sarcoma virus
Features:
Provides access to powerful functional screening capabilities of retroviral technology
Inventors:
D. Blair, M Oskarsson, W. Mcclements, G. Vande Woude
HHS Institute/Agency:
NCI
Licensee:
Stratagene California  
Market Launch:
1997
1999
Product Name:
LTR-Vectors
Use:
Used to make retroviral vectors for development of gene therapy products
HHS Contribution:
Developed LTR sequences
Features:
Provides access to powerful functional screening capabilities of retroviral technology
Inventors:
G. Vande Woude, D. Blair, W. Mcclements, M. Oskarsson
HHS Institute/Agency:
NCI
Licensee:
Novartis Pharma, Genetic Therapy, Inc.  
Market Launch:
1999
1999
Product Name:
LYMErix™
Use:
A noninfectious recombinant vaccine for Lyme's disease
HHS Contribution:
Generated the expression vector pAS1 used for large scale recombinant protein production
Features:
The first vaccine for the prevention of Lyme's disease
Inventors:
M. Rosenberg
HHS Institute/Agency:
NCI
Licensee:
GlaxoSmithKline 
Market Launch:
1999
1997
Product Name:
Macrophage Stimulating Protein
Use:
Activates macrophages to react in the immune system
HHS Contribution:
Discovered a method to purify macrophage stimulating proteins and found that it can be used as a pathogen against infection.
Features:
Significantly impacts the role of macrophages to immune responses
Inventors:
E. Appella, T. Yoshimura, A. Skeel, E. Leonard
HHS Institute/Agency:
NCI
Licensee:
Research and Diagnostic Systems, Inc.  
Market Launch:
1997
2004
Product Name:
MART-1 Antibody
Use:
Diagnostic assay for metastatic melanoma
HHS Contribution:
Identified the immunodominant peptides of the MART-1 human melanoma antigen.
Features:
Can be used in Flow Cytometry, Immunoprecipitation, Western Blot, and Immunohistochemistry.
Inventors:
Y. Kawakami and P. Robbins
HHS Institute/Agency:
NCI
Licensee:
Cell Marque Corporation  
Market Launch:
2004
1993
Product Name:
Matrigel®
Use:
Substrate for culturing cells
HHS Contribution:
Reconstituted basement membrane complex with biological activity
Features:
Allows studying natural cellular behaviors otherwise not observed in the lab
Inventors:
H. Kleinman and G. Martin
HHS Institute/Agency:
NIDCR
Licensee:
Becton Dickinson 
Market Launch:
1993
1997
Product Name:
Melanoma-associated antigen recognized by T cells (MART-1) Antibodies
Use:
This antibody is very useful in establishing the diagnosis of metastatic melanomas
HHS Contribution:
Provided a nucleic acid sequence encoding a melanoma antigen recognized by T lymphocytes, designated MART-1
Features:
Anti-MART-1 is a mouse monoclonal antibody from tissue culture supernatant diluted in phosphate buffered saline, pH 7.4 etc.
Inventors:
Y. Kawakami
HHS Institute/Agency:
NCI
Licensee:
Signet Laboratories, Inc.  
Market Launch:
1997
2003
Product Name:
Melanoma-associated antigen recognized by T cells (MART-1) Melan A
Use:
Labels melanomas and tumors showing melanocytic differentiation
HHS Contribution:
Provided a nucleic acid sequence encoding a melanoma antigen recognized by T lymphocytes, designated MART-1
Features:
Useful addition to melanoma panels which are specific to melanocytic lesions
Inventors:
Y. Kawakami
HHS Institute/Agency:
NCI
Licensee:
Biocare Medical, LLC  
Market Launch:
2003
2005
Product Name:
Mesothelin (K1)
Use:
Used as a therapeutic for mesotheliomas and pancreatic and ovarian tumors
HHS Contribution:
Generated an anti-mesothelin antibody of human origin
Features:
Can be a diagnostic for the detection of mesothelin positive tumors
Inventors:
D. Dimitrov
HHS Institute/Agency:
NCI
Licensee:
Santa Cruz Biotechnology, Inc.  
Market Launch:
2005
1997
Product Name:
Micro HTLV-1/2
Use:
Uses multiple antigens to detect HTLV-1 and HLTV-2
HHS Contribution:
Discovered recombinant HIV envelope proteins to be used in detection assays
Features:
Valuable tool to help detect HTLV
Inventors:
T. Papas
HHS Institute/Agency:
NCI
Licensee:
Abbott Laboratories, Inc.  
Market Launch:
1997
1998
Product Name:
Microsomes, S9 Fractions and Cytosol
Use:
Used for Cytochrome p450 inhibition and phenotyping
HHS Contribution:
Found that MAb 49-10-20 is inhibits and binds to 2B6
Features:
Can choose the liver microsomes and liver S9 fractions from a variety of p450s
Inventors:
H. Gelboin
HHS Institute/Agency:
NCI
Licensee:
Invitrogen Corporation  
Market Launch:
1998
1997
Product Name:
Monoclonal Antibodies to HIV-1
Use:
Identify and trace specific cells or molecules in an organism
HHS Contribution:
Developed monoclonal antibodies for binding HTLV-III proteins and cell lines for their production
Features:
Helps study HIV antigen tissue sections.
Inventors:
M. Sargnadharan, R. Gallo, F. Veronese
HHS Institute/Agency:
NCI
Licensee:
Intracel Corporation  
Market Launch:
1997
1993
Product Name:
Monoclonal antibody
Use:
Markers used for identifying breast cancer cells
HHS Contribution:
Process for Producing Monoclonal Antibodies Reactive with Human Breast Cancer
Features:
Effective in immunofluorescence and immunohistochemistry
Inventors:
J. Schlom, D. Colcher, M. Nuti, P. Hand, F. Austin
HHS Institute/Agency:
NCI
Licensee:
Signet Laboratories, Inc.  
Market Launch:
1993
1995
Product Name:
Monoclonal antibody J52 and C3
Use:
Identify and trace specific cells or molecules in an organism
HHS Contribution:
Developed Monoclonal Antibodies to Cytosolic Thyroid Binding Protein
Features:
Successfully used in Western blot, immunocytochemistry, immunoprecipitation and gel shift procedures.
Inventors:
S. Cheng
HHS Institute/Agency:
NCI
Licensee:
Affinity BioReagents, Inc.  
Market Launch:
1995
1996
Product Name:
Monoclonal Antibody to human CD82
Use:
Identify and trace specific cells or molecules in an organism
HHS Contribution:
Developed monoclonal antibody to human CD82 produced by Clone 50F11
Features:
Plays a role in signal transduction and adhesion
Inventors:
J. Shaw
HHS Institute/Agency:
NCI
Licensee:
BD Biosciences - BD PharMingen  
Market Launch:
1996
1997
Product Name:
Monocyte chemotactic protein-1 Antibodies
Use:
Antibody reacts with mouse/rat/human Monocyte chemotactic protein-1 and is used to detect Monocyte chemotactic protein-1
HHS Contribution:
Discovered that MCP-1 is secreted by PHA-stimulated mononuclear proteins and attracts monocytes
Features:
May be use as a neutralizing antibody
Inventors:
T. Yoshimura
HHS Institute/Agency:
NCI
Licensee:
BD Biosciences - BD PharMingen  
Market Launch:
1997
1998
Product Name:
Mouse anti-14-3-3 epsilon
Use:
Anti-14-3-3 ε recognizes the expressed product of the YWHAE gene, also known as Ywhae.
HHS Contribution:
Discovered an enhanced method of killing tumor cells with human effector cells, such as lymphocytes.
Features:
Enhances the kinase activity of the Raf proto-oncogene and Ras resulting in a kinase signaling pathway
Inventors:
J. Ortaldo
HHS Institute/Agency:
NCI
Licensee:
BD Biosciences - BD PharMingen  
Market Launch:
1998
1996
Product Name:
Mouse Mammary Tumor Virus-bla HeLa Cell Line
Use:
Allows for the analysis of endogenous glucocorticoid receptor signaling
HHS Contribution:
Describes retrovirus Long Termical Repeat vectors and model systems involving LTR vectors derived from the Moloney sarcoma virus
Features:
Has been thoroughly tested for assay performance under different circumstances
Inventors:
D. Blair, M Oskarsson, W. Mcclements, G. Vande Woude
HHS Institute/Agency:
NCI
Licensee:
Invitrogen Corporation  
Market Launch:
1996
1998
Product Name:
Murine D551 antibody
Use:
Identify PLK enzymes in vitro
HHS Contribution:
Developed mu-1883 PLK-peptide
Features:
Specific for mouse PLK identification
Inventors:
D. Ferris
HHS Institute/Agency:
NCI
Licensee:
Upstate Biotechnology, Incorporated  
Market Launch:
1998
1997
Product Name:
Murine Stem Cell Virus Retroviral Expression System
Use:
Contains 3 vectors: pMSCVneo, pMSCVhyg, and pMSCVpuro that enhances research to be done with hard-to-transduce cell lines
HHS Contribution:
Describes retrovirus Long Terminal Peteat vectors and model systems involving LTR vectors derived from the Moloney sarcoma virus
Features:
Changes in the Long Terminal Repeat enhance transcriptional activation and prevent transcriptional suppression in ES and EC cells.
Inventors:
D. Blair, M Oskarsson, W. Mcclements, G. Vande Woude
HHS Institute/Agency:
NCI
Licensee:
Clontech Laboratories, Inc  
Market Launch:
1997
1996
Product Name:
MutaPlax cII-Select Kit
Use:
Measures mutation frequencies of lambda-based in vivo mutagenesis systems using a new positive selection method.
HHS Contribution:
A novel assay for the detection of mutations in the lambda transgene
Features:
Includes MutaPlax™ lambda packaging extracts from NM759 and an extract from strain BHB2688.
Inventors:
S. Garges, S. Adhya, J. Jakubczak, G. Merlino
HHS Institute/Agency:
NCI
Licensee:
Epicentre Technologies Corporation  
Market Launch:
1996
1998
Product Name:
NeoTect®
Use:
Serves as an imaging agent for radiation scans of lung lesions in cancer patients and patients at high-risk for cancer
HHS Contribution:
Chemical procedure for creating the complex, custom-designed peptides and peptide-based reagents
Features:
Offers a less expensive and virtually painless method for determining the malignancy of lung masses
Inventors:
F. Robey
HHS Institute/Agency:
NIDCR
Licensee:
Berlex Laboratories, Inc.  
Market Launch:
1998
1994
Product Name:
NeuTrexin® (Trimetrexate)
Use:
Treatment for infections due to toxoplasma gondii and pneumocystis carinii in immunocompromised patients, including patients with AIDS
HHS Contribution:
Active compound Trimetrexate used as antiparasitic agent in AIDs treatment
Features:
Available as a sterile lyophilized powder
Inventors:
C. Allegra, B. Chabner, J. Drake
HHS Institute/Agency:
NCI
Licensee:
MedImmune Oncology  
Market Launch:
1994
1994
Product Name:
Nitric Oxide Complexes with Polyamines
Use:
Used for the treatment of cardiovascular disorders
HHS Contribution:
Developed novel complexes of Nitric Oxide with Polyamines
Features:
Compounds release nitric oxide (endothelium-derived relaxing factor) under physiological conditions in a sustained and controllable fashion
Inventors:
L. Keefer, J. Harbie
HHS Institute/Agency:
NCI
Licensee:
Dojindo Laboratories  
Market Launch:
1994
2007
Product Name:
Nitric oxide donor {Glycosylated Diazen-Pyrrolidin-1,2-diolates}
Use:
Research tool/reagent for nonhuman investigations
HHS Contribution:
Production of nitric oxide donor, anti-proliferative
Features:
Sigma contains a great variety of NO donors for study
Inventors:
J. Saavedra, A. Srinivasan, L. Keefer
HHS Institute/Agency:
NCI
Licensee:
Sigma Chemical Corporation  
Market Launch:
2007
2005
Product Name:
O6-Benzylguanine
Use:
Employed in various DNA repair mechanism studies
HHS Contribution:
Developed O6-substituted Guanine compounds and methods for depleting O6-Alkylguanine-DNA Alkyltransferase levels
Features:
Involved in the inhibition of AGT-mediated DNA repair
Inventors:
R. Moschel
HHS Institute/Agency:
NCI
Licensee:
Sigma Chemical Corporation  
Market Launch:
2005
2003
Product Name:
Ocuvite® PreserVision
Use:
Nutritional supplement to treat macular degeneration
HHS Contribution:
Unique formulation of nutritional supplement
Features:
First NIH licensed technology in an FDA approved product to be sold over the counter
Inventors:
F. Ferris
HHS Institute/Agency:
NEI
Licensee:
Bausch and Lomb 
Market Launch:
2003
1994
Product Name:
OncoScint Mab
Use:
Serves as a antibody based radiolabeling agent that detects colorectal and ovarian cancer
HHS Contribution:
Produced the antibodies that are reactive with human breast cancer
Features:
Offers a less expensive alternative to PET scans and more widely available
Inventors:
J. Schlom, C. Austin, D. Colcher, P. Hand, M. Nuti
HHS Institute/Agency:
NCI
Licensee:
Cytogen Corporation  
Market Launch:
1994
1996
Product Name:
P450 BACULOSOMES® Reagents
Use:
Used for Cytochrome p450 inhibition and phenotyping
HHS Contribution:
Isolated cDNAs of many human cytochrome p450s and discovered it's expression location among other things
Features:
Infected with recombinant baculovirus containing a cDNA insert for a human P450 to prevent metabolism of other p450s
Inventors:
F. Gonzales, H. Gelboin
HHS Institute/Agency:
NCI
Licensee:
PanVera LLC  
Market Launch:
1996
1999
Product Name:
Parvovirus B19 Immunoassay
Use:
Detection of B19 virus IgM antibodies in human serum and plasma
HHS Contribution:
Recombinant capsid proteins and antibodies against them.
Features:
First diagnostic test for parvovirus B19 infection approved by the FDA
Inventors:
N. Young
HHS Institute/Agency:
NHLBI
Licensee:
University of Leiden (Sub-licensed: Biotrin International) 
Market Launch:
1999
1998
Product Name:
PathVysion® HER-2 DNA Probe Kit
Use:
Prognosis of breast cancer (in conjunction with other clinical data)
HHS Contribution:
Connection of HER2 gene with breast cancer.
Features:
First NIH licensed technology in an FDA approved product to be used in personalized medicine
Inventors:
C. King
HHS Institute/Agency:
NCI
Licensee:
Abbott Molecular Inc. 
Market Launch:
1998
1998
Product Name:
Pathway® Her-2/neu (4B5)
Use:
Assessment of breast cancer patients for whom Herceptin� treatment is considered.
HHS Contribution:
Connection of HER2 gene with breast cancer.
Features:
Second NIH licensed technology in an FDA approved product to be used in personalized medicine
Inventors:
C. King
HHS Institute/Agency:
NCI
Licensee:
Ventana Medical Systems, Inc. 
Market Launch:
1998
1993
Product Name:
pBH10 HIV Clone
Use:
HIV research tool
HHS Contribution:
Developed this HIV-1 genomic clone
Features:
Not infectious in present form
Inventors:
R. Gallo
HHS Institute/Agency:
NCI
Licensee:
Aros Biotech AB  
Market Launch:
1993
2007
Product Name:
PDGFR-α (αR1): sc-32287 (antibody)
Use:
Recommended for detection of PDGFR-α of human origin by IF and FCM
HHS Contribution:
Method for making monoclonal antibodies to alpha Platelet-Derived Growth Factor Receptor (PDGFR)
Features:
Useful for studying relations with chronicmyelomonocyticleukemia
Inventors:
T. Matsui, S. Aaronson, J. Pierce
HHS Institute/Agency:
NCI
Licensee:
Santa Cruz Biotechnology, Inc.  
Market Launch:
2007
2004
Product Name:
Phosphotyrosine mimicking amino acid
Use:
Used as a building block for the synthesis of cell-permeable protein tyrosine phospatase (PTP) inhibitors
HHS Contribution:
Developed O-Malonyl Tyrosyl – Containing SH2 Domain Inihbitors
Features:
Inhibited PTP 1B 20 times more potently than the corresponding phosphotyrosine containing peptide
Inventors:
T. Burke, M. Akamatsu, H. Kole, P. Roller, B. Ye
HHS Institute/Agency:
NCI
Licensee:
Bachem Holding AG  
Market Launch:
2004
1997
Product Name:
PixCell
Use:
Laser Capture Microdissection (LCM) is used for microdissection of single cells or small number of cells
HHS Contribution:
Laser Capture Microdissection (LCM) technique
Features:
Ensures biological molecules like RNA and DNA remain undamaged in the micro-dissection process
Inventors:
L. Liotta and R. Bonner
HHS Institute/Agency:
NCI
Licensee:
Arcturus Engineering, Inc.  
Market Launch:
1997
1996
Product Name:
Platelet derived growth factor HU CD140A MAb
Use:
Reacts with platelet derived growth factor (PDGF) receptor α
HHS Contribution:
Methods to determine the growth of neoplasia using a monoclonal antibody against platelet derived growth factor receptor
Features:
This antibody is routinely tested by flow cytometric analysis.
Inventors:
W. Larochelle, S. Aaronson
HHS Institute/Agency:
NCI
Licensee:
BD Biosciences - BD PharMingen  
Market Launch:
1996
1997
Product Name:
Polyclonal Antibody to HIV-1 Rabbit anti Protease
Use:
Detects mature and precursor proteases
HHS Contribution:
Identified and sequenced the HIV protease necessary for the natural synthesis of HIV
Features:
Binds to recombinant protease (HIV-1)
Inventors:
S. Oroszlan,T. Copeland
HHS Institute/Agency:
NCI
Licensee:
Intracel Corporation  
Market Launch:
1997
2000
Product Name:
PPAR alpha-deficient mouse
Use:
Mouse model used to study biochemical mechanism involved in cholesterol lowering drugs.
HHS Contribution:
Created mouse with PPAR gene knocked out.
Features:
The colony is maintained by incrossing homozygous mice.
Inventors:
F. Gonzales
HHS Institute/Agency:
NCI
Licensee:
Taconic Farm, Inc.  
Market Launch:
2000
2006
Product Name:
Prezista®
Use:
Treatment of patients with HIV-1 strains resistant to more than one protease inhibitor
HHS Contribution:
Robust HIV protease inhibitor
Features:
Second-generation protease inhibitor that overcomes resistance to older agents in this class
Inventors:
J. Erickson
HHS Institute/Agency:
NCI
Licensee:
Tibotec Pharmaceuticals, Ltd. 
Market Launch:
2006
2001
Product Name:
Prolactin Receptor Ab-1 and Hybridoma
Use:
Detects and binds to prolactin receptors
HHS Contribution:
Developed the B6.2 secreting antibody to the Prolactin Receptor
Features:
Involved in the stimulation of milk production, salt and water regulation, growth, development and reproduction.
Inventors:
F. Austin, P. Hand, M. Nuti, D. Cocher, J. Schlom
HHS Institute/Agency:
NCI
Licensee:
NeoMarkers, Inc.  
Market Launch:
2001
1997
Product Name:
ProNectin®
Use:
Used to coat a wide variety of cell culture containers and materials due to its unique ability to promote cell attachment
HHS Contribution:
Genetically engineered protein polymers for use as research reagents
Features:
Provides consistent performance and stability without any animal-derived contaminants
Inventors:
Y. Yamada
HHS Institute/Agency:
NIDCR
Licensee:
Sanyo Chemical Industries, Ltd.  
Market Launch:
1997
2000
Product Name:
Pteridine Oligonucleotides
Use:
Due to exquisite sensitivity to changes in the environment, they can be used for the study of DNA interactions.
HHS Contribution:
Provided novel pteridine nucleotides which may be used in the chemical synthesis of fluorescent oligonucleotides
Features:
Very high quantum yield. Perfect for diagnostic applications
Inventors:
M. Hawkins, W. Pfleiderer, M. Davis, F. Balis
HHS Institute/Agency:
NCI
Licensee:
TriLink BioTechnologies, Inc.  
Market Launch:
2000
2001
Product Name:
QualiCode™ HIV-1/2
Use:
Screens for the presence of antibodies to HIV-1 and HIV-2.
HHS Contribution:
Detected antibodies to HIV in serum of patients with AIDS and pre-AIDS conditions, and linked the HIV virus to AIDS
Features:
Often used as a confirmatory test as other HIV tests are more likely to give false negatives.
Inventors:
R. Gallo, L. Montagnier, and R. Crowl
HHS Institute/Agency:
NCI
Licensee:
OraSure Technologies, Inc.  
Market Launch:
2001
1998
Product Name:
QualiCode™ HIV - 1/2 Western Blot Kit
Use:
Screens for the presence of antibodies to HIV-1 and HIV-2.
HHS Contribution:
Detected antibodies to HIV in serum of patients with AIDS and pre-AIDS conditions, and consequently, linked the HIV virus to AIDS
Features:
Often used as a confirmatory test as other HIV tests are more likely to give false negatives.
Inventors:
R. Gallo, L. Montagnier, and R. Crowl
HHS Institute/Agency:
NCI
Licensee:
Immunetics, Inc.  
Market Launch:
1998
2002
Product Name:
Quantikine®
Use:
Designed for the quantitative determination of activated human TGF-b1 concentrations in cell culture supernatant, serum, plasma, and urine
HHS Contribution:
Immunoassay for detection of TGF or an EGF or both.
Features:
A useful kit for the quantitative determination of TGF-beta 1
Inventors:
M. Sporn
HHS Institute/Agency:
NCI
Licensee:
R&D Systems, Inc.  
Market Launch:
2002
1993
Product Name:
Ras p21 ELISA
Use:
Use for the quantitation of circulating ras p21 in human serum and plasma
HHS Contribution:
Obtained five separate monoclonal antibodies that immunoprecipitate (raf)-1 oncoprotein
Features:
Uses a mouse monoclonal Capture Antibody and a biotinylated mouse monoclonal antibody as detector.
Inventors:
U. Rapp
HHS Institute/Agency:
NCI
Licensee:
Oncogene Sciences, Inc.  
Market Launch:
1993
1995
Product Name:
Recombinant HIV-1 protease in bacteria
Use:
Used for designing HIV protease inhibitors, which serves as an important component of combination therapies for HIV
HHS Contribution:
Discovered human immunodeficiency virus specific proteolytic enzyme and developed method for synthesis and renaturation
Features:
Can possibly be used in the treatment of patients with AIDS
Inventors:
S. Oroszlan, T. Copeland
HHS Institute/Agency:
NCI
Licensee:
Veritas, Inc.  
Market Launch:
1995
1997
Product Name:
Recombinant HTLV-1 p21
Use:
Used for ELISA and western blot studies.
HHS Contribution:
Antigenic proteins may be expressed in bacteria using vectors and the proteins are useful in identifying antibodies to the organisms from which the DNA fragments were originally obtained.
Features:
Recognized by antibodies in HTLV-1 positive serum in ELISA and Western Blot
Inventors:
T Papas,
HHS Institute/Agency:
NCI
Licensee:
Intracel Corporation  
Market Launch:
1997
1995
Product Name:
Recombinant Human Interleukin-2
Use:
IL­2 plays a central role in the expansion and  maintenance of regulatory T cells
HHS Contribution:
Created a sandwich method and a kit for assaying interleukin-2 receptor (IL-2R) in a sample.
Features:
Produced in E. Coli cells
Inventors:
R. Yarchoan, W. Leonard, D. Nelson
HHS Institute/Agency:
NCI
Licensee:
R&D Systems, Inc.  
Market Launch:
1995
2002
Product Name:
Recombinant Human sFRP-4
Use:
sFRPs contain cysteine-rich domain Wnt ligands in Frizzleds that provides a novel, secreted protein that contains a region homogulous to ligand binding domain of a cytokine receptor.
HHS Contribution:
This protein, called Frizzled-related protein (FRP), antagonizes the signaling of the Wnt family of cytokines.
Features:
This protein shows complex functions with respect to cell survival
Inventors:
J. Rubin, S Aaronson
HHS Institute/Agency:
NCI
Licensee:
Techne Corporation 
Market Launch:
2002
1996
Product Name:
Recombinant Pseudomonas Exotoxins
Use:
Used to target the Lewis-Y antigen for therapeutic and diagnostic purposes
HHS Contribution:
Developed the recombinant pseudomonas exotoxin
Features:
The first active immunotoxin with low side effects
Inventors:
I. Pastan, D. Fitzgerald
HHS Institute/Agency:
NCI
Licensee:
Bristol-Myers Squibb Company  
Market Launch:
1996
2006
Product Name:
Recombitek® C4
Use:
Vaccine for dogs against distemper, parvovirus, hepatitis, respiratory disease and parainfluenza virus.
HHS Contribution:
Canarypox-based vector that can enter but not replicate in mammals
Features:
First and only such vaccine in the U.S. that uses canarypox-vectored technology
Inventors:
B. Moss
HHS Institute/Agency:
NIAID
Licensee:
Merial Limited 
Market Launch:
2006
2006
Product Name:
Recombitek® Canine Corona - MLV
Use:
Vaccine for dogs against prevention of diesease due to canine coronavirus
HHS Contribution:
Canarypox-based vector that can enter but not replicate in mammals
Features:
First and only canine coronavirus vaccine in the U.S. that uses canarypox-vectored technology
Inventors:
B. Moss
HHS Institute/Agency:
NIAID
Licensee:
Merial Limited 
Market Launch:
2006
2006
Product Name:
Recombitek® Equine Influenza
Use:
Vaccine for horses against equine influenza virus.
HHS Contribution:
Canarypox-based vector that can enter but not replicate in mammals
Features:
First and only equine influenza virus vaccine in the U.S. that uses canarypox-vectored technology
Inventors:
B. Moss
HHS Institute/Agency:
NIAID
Licensee:
Merial Limited 
Market Launch:
2006
2006
Product Name:
Recombitek® West Nile Virus
Use:
Vaccine for horses as an aid in the prevention of viremia due to West Nile Virus
HHS Contribution:
Canarypox-based vector that can enter but not replicate in mammals
Features:
First and only equine West Nile Virus vaccine in the U.S. that uses canarypox-vectored technology
Inventors:
B. Moss
HHS Institute/Agency:
NIAID
Licensee:
Merial Limited 
Market Launch:
2006
1996
Product Name:
Resiniferatoxin
Use:
Involved in the transmission of pain signals
HHS Contribution:
Labeled resiniferatoxin
Features:
Purity of resiniferatoxin is checked at appropriate intervals using a chromatography method
Inventors:
P. Blumberg,
HHS Institute/Agency:
NCI
Licensee:
DuPont NEN Products  
Market Launch:
1996
2001
Product Name:
Reveal™ G3 Rapid HIV-1 Antibody Test
Use:
Used to detect HIV in serum or plasma
HHS Contribution:
Propagation of HIV in the lab and detection of HIV antibodies.
Features:
Rapid (5 minute) detection of exposure to HIV
Inventors:
R. Gallo, L. Montagnier, and R. Crowl
HHS Institute/Agency:
NCI
Licensee:
MedMira Laboratories, Inc. 
Market Launch:
2001
2000
Product Name:
Rhodamine Green Heptagastrin
Use:
Useful tool for the study of endocytosis
HHS Contribution:
Rhodamine Green-heptagastrin is found to specifically bind to NIH/3T3 cells transfected with human gastrin/CCKB receptor cDNA
Features:
Quantitative estimation of binding and determination of Kd
Inventors:
C. Michejda, N. Tarasova
HHS Institute/Agency:
NCI
Licensee:
Boston Biologicals Inc.  
Market Launch:
2000
2005
Product Name:
SiHa Cell Line - Negative Control
Use:
Detects HPV DNA in human cervical samples
HHS Contribution:
Developed the SiHa and H9 cell lines
Features:
Contains a mix of infected and non-infected cells for research
Inventors:
Yohei Ito
HHS Institute/Agency:
NCI
Licensee:
BBI-Biotech Research Laboratories, Inc.  
Market Launch:
2005
1997
Product Name:
Sporanox® Oral Solution
Use:
Treatment of painful and debilitating fungal infections of the esophagus and mouth, commonly called thrush.
HHS Contribution:
Solubilization of the compound to make it easier for the body to absorb the drug
Features:
First use of itraconazole in a soluble compound for the treatment of oral thrush
Inventors:
J. Pitha
HHS Institute/Agency:
NIA
Licensee:
Janssen Pharmaceutica Products, L.P.  
Market Launch:
1997
1995
Product Name:
Squirrel Free Bird Seed
Use:
Capsaicin-coated birdseed unpalatable to rodents
HHS Contribution:
Treated bird seed preferentially palatable to birds but not palatable to animals having chili pepper sensitive receptors
Features:
Chili peppers are a good source of nutrients for birds as well as vitamin A, vitamin D, and carotene
Inventors:
P. Blumberg
HHS Institute/Agency:
NCI
Licensee:
Dun-Frey Partnership  
Market Launch:
1995
1998
Product Name:
Synagis®
Use:
For prevention/treatment of respiratory syncytial virus (RSV)
HHS Contribution:
Derivation of monoclonal antibodies directed against RSV
Features:
First monoclonal antibody approved by the FDA for an infectious disease.
Inventors:
B. Murphy et al.
HHS Institute/Agency:
NIAID
Licensee:
MedImmune, Inc. 
Market Launch:
1998
1990
Product Name:
Synthetic Oligodeoxyribonucleotides
Use:
Inhibits production of disease-causing proteins
HHS Contribution:
Discovered that Phosphorothioate oligodeoxyribonucleotide analogs can prevent the replication of foreign nucleic acids in the presence of normal living cells.
Features:
Able to inhibit the production of disease-causing proteins
Inventors:
Cy A. Stein, L. Neckers, S. Loke, J Cohen, M Matsukura, K. Shinozuka, G. Zon
HHS Institute/Agency:
NCI
Licensee:
Inex Pharmaceuticals Corp 
Market Launch:
1990
1994
Product Name:
TAG-72/CA72-4 Ab-1 (Clone B72.3)
Use:
Monoclonal Ab used for the detection of the TAG-72 antigen expressed on cancer cells. Useful in distinguishing pulmonary adenocarcinomas from pleural mesotheliomas.
HHS Contribution:
Discovered process for producing monoclonal antibodies that aid in the diagnosis, prognosis and treatment of human breast cancer
Features:
Ab-1 is reportedly useful in distinguishing pulmonary adenocarcinomas (B72.3+) from pleural mesotheliomas (B72.3-)
Inventors:
J. Schlom
HHS Institute/Agency:
NCI
Licensee:
NeoMarkers, Inc.  
Market Launch:
1994
1992
Product Name:
Taxol®
Use:
Treatment of advanced carcinoma of the ovary and as adjuvant treatment of node-positive breast cancer
HHS Contribution:
Improved the method for administering paclitaxel
Features:
Extensive clinical development was done by NCI
Inventors:
G. Vande Woude, W. Wilson, and E. Reed
HHS Institute/Agency:
NCI
Licensee:
Bristol-Myers Squibb Company 
Market Launch:
1992
2004
Product Name:
TAXUS® Express 2
Use:
Paclitaxel-eluting stent used to prevent restenosis after ballon angioplasty of coronary peripheral arteries
HHS Contribution:
Discovered that localized release of paclitaxel prevents artery narrowing from cell growth
Features:
Largest 1st year sales of any FDA approved product in U.S. history
Inventors:
J. Kinsella and S. Sollott
HHS Institute/Agency:
NIA
Licensee:
Angiotech Pharmaceuticals and Boston Scientific 
Market Launch:
2004
1998
Product Name:
Thyrogen®
Use:
Diagnostic tool used in follow-up of patients with specific thyroid cancers
HHS Contribution:
Recombinant form of human thyroid stimulating hormone (TSH)
Features:
Allows treatment of thyroid cancer and obtain reliable diagnostic test results for the recurrence of cancer
Inventors:
F. Wondisford
HHS Institute/Agency:
NIDDK
Licensee:
Genzyme Diagnostics 
Market Launch:
1998
1996
Product Name:
Thyroid hormone Receptor interactor (TRIP13) Monoclonal Antibody (3A5)
Use:
Labels thyrotroph cells of the anterior pituitary and the benign and malignant neoplasms that are derived from these cells.
HHS Contribution:
Screened antibodies reactive to thyroid hormone receptor interactor
Features:
Useful and effective in immunohistochemistry
Inventors:
S. Cheng
HHS Institute/Agency:
NCI
Licensee:
Stressgen Bioreagents Limited Partnership  
Market Launch:
1996
1998
Product Name:
Thyroid Stimulating Hormone (TSH) Polyclonal Antibody
Use:
It stains the thyrotroph cells of the anterior pituitary and the benign and malignant neoplasms that are derived from these cells.
HHS Contribution:
Screened for antibodies that inhibited thyroid hormones to its domain
Features:
Useful and effective in immunohistochemistry
Inventors:
S. Cheng
HHS Institute/Agency:
NCI
Licensee:
Covance Research Products, Inc.  
Market Launch:
1998
1994
Product Name:
TIMP-1 ELISA
Use:
For the quantitation of inhibitor tissure of metalloproteinase-1 in human serum and plasma.
HHS Contribution:
The Metalloproteinase peptide invention is an isolated protein of approximately 23,000 daltons in size that binds to metalloproteinases, and is potentially useful for the detection metalloproteinases.
Features:
Provides with a convenient, accurate, and reproducible method to determine TIMP-1 levels in human serum or plasma
Inventors:
W. Stetler-Stevenson
HHS Institute/Agency:
NCI
Licensee:
Oncogene Sciences, Inc.  
Market Launch:
1994
2005
Product Name:
TIMP-2 ELISA Kits
Use:
The TIMP-2 immunoassay kit utilizes antibodies immobilized on a bead matrix directed against different antigenic sites on the same TIMP-2 molecule.
HHS Contribution:
The Metalloproteinase peptide invention is an isolated protein that binds to metalloproteinases with high affinity and is potentially useful for therapy of pathologic conditions of low production metalloproteinases
Features:
The TIMP-2 immunoassay kit is useful for the determination of TIMP-2 levels in fresh serum and conditioned medium of cells.
Inventors:
W. Stetler-Stevenson
HHS Institute/Agency:
NCI
Licensee:
Fuji Chemical Industries, Ltd.  
Market Launch:
2005
2002
Product Name:
TS 106 antibodies (against Human Thymidylate Synthase)
Use:
Used as a research reagent to enhance the understanding of certain cancers that exhibit elevated expression of thymidylate synthase
HHS Contribution:
Developed monoclonal antibodies for Human Thymidylate Synthase
Features:
A critical target enzyme in cancer chemotherapy
Inventors:
P. Johnston, C. Allegra, B. Chabner, C. Liang
HHS Institute/Agency:
NCI
Licensee:
Zymed Laboratories, Inc.  
Market Launch:
2002
1998
Product Name:
Tumor Associated Antigen Antibodies
Use:
The various antibodies serve as markers for the different kinds of tumors.
HHS Contribution:
Discovered Melanoma antigens and their use in diagnostic and therapeutic methods
Features:
They are excellent for staining of formalin-fixed tissues.
Inventors:
Y. Kawakami
HHS Institute/Agency:
NCI
Licensee:
NeoMarkers, Inc.  
Market Launch:
1998
2001
Product Name:
Twinrix®
Use:
Vaccine against Hepatitis A plus Hepatitis B
HHS Contribution:
Propagation of Hepatitis A virus in cell culture rather than animal hosts
Features:
Simplifies vaccination to Hepatitis
Inventors:
R. Daemer
HHS Institute/Agency:
NIAID
Licensee:
GlaxoSmithKline 
Market Launch:
2001
2001
Product Name:
Various Anti-HMG & Anti-Histone products
Use:
Used as research reagents for studies on the molecular basis of disease
HHS Contribution:
Developed Anti-HMG-17, Anti-HMG-14, Anti-Histone Hlo/H5, Anti-Histone H4 and Anti-HMG-1 Sera
Features:
Evaluated by western blot in RIPA lysates from Hep-G2 cells
Inventors:
M. Bustin
HHS Institute/Agency:
NCI
Licensee:
Upstate Biotechnology, Incorporated  
Market Launch:
2001
2003
Product Name:
Velcade®
Use:
Treatment for multiple myeloma that works by specifically inhibiting an enzyme complex known as the proteosome.
HHS Contribution:
Creation of a freeze-dried powder formulation of boronic acid compounds resulting in longer stable shelf life
Features:
First proteosome inhibitor to be approved by the FDA
Inventors:
S. Gupta
HHS Institute/Agency:
NCI
Licensee:
Millennium Pharmaceuticals, Inc. 
Market Launch:
2003
1991
Product Name:
Videx®
Use:
Treatment of advanced HIV infection in adults or children older than 6 months
HHS Contribution:
Screening of dideoxy inosine for anti-viral activity, preclinical and toxicology research, early clinical development
Features:
Second drug approved for the treatment of HIV infection
Inventors:
H. Mitsuya
HHS Institute/Agency:
NCI
Licensee:
Bristol-Myers Squibb Company 
Market Launch:
1991
1998
Product Name:
Vironostika® HTLV-I/II
Use:
Screens for HTLV-I/II
HHS Contribution:
Developed a cell line that produces monoclonal antibody 2A66 against HTLV-II p19
Features:
Produces same day, reliable results
Inventors:
M. Robert-Gruoff, R. Gallo
HHS Institute/Agency:
NCI
Licensee:
Organon Teknika  
Market Launch:
1998
2001
Product Name:
Vironostika® HTLV-I/II
Use:
Screens for HTLV-I/II
HHS Contribution:
Developed a cell line that produces monoclonal antibody 2A66 against HTLV-II p19
Features:
Produces same day, reliable results
Inventors:
M. Robert-Guroff, R. Gallo
HHS Institute/Agency:
NCI
Licensee:
BioMerieux, Inc.  
Market Launch:
2001
1998
Product Name:
Vitravene™
Use:
Inhibition of CMV eye infections
HHS Contribution:
Discovery that using phosphorothioate oligonucleotides as DNA backbones results in effective anti-viral compounds that are more stable in human cells
Features:
First antisense therapeutic approved for use in humans
Inventors:
J. Cohen
HHS Institute/Agency:
NCI
Licensee:
Isis Pharmaceuticals, Inc. 
Market Launch:
1998
1999
Product Name:
VIVID® CYP1A2 Blue Screening Kit
Use:
Used for the detection of enzyme-drug interactions and CYP450 inhibition
HHS Contribution:
Discovered agents that bind to and inhibit human cytochrome P450 1A2
Features:
Provides an optimized method for studying isozyme-specific CYP450 drug.
Inventors:
H. Gelboin
HHS Institute/Agency:
NCI
Licensee:
Invitrogen Corporation  
Market Launch:
1999
1998
Product Name:
VIVID® CYP3A4 Red Screening Kit
Use:
Enables fast measurements of interactions between drug candidates and cytochrome p450 enzymes.
HHS Contribution:
Described antigen binding polypeptides that specifically bind to many human cytochrome p450s.
Features:
Will allow investigators to rapidly identify interactions of CYP450
Inventors:
H. Gelboin. F. Gonzalez
HHS Institute/Agency:
NCI
Licensee:
Invitrogen Corporation  
Market Launch:
1998
1997
Product Name:
Zenapax®
Use:
Prevention of acute kidney transplant rejection
HHS Contribution:
Use of an antibody to the IL-2 receptor for treating malignancy and autoimmune disorders.
Features:
noninfectious recombinant vaccine
Inventors:
T. Waldman
HHS Institute/Agency:
NCI
Licensee:
Protein Design Laboratory / Hoffman LaRoche 
Market Launch:
1997
2002
Product Name:
Zevalin®
Use:
Treatment of patients with relapsed or refractory B-cell non-Hodgkin's lymphoma.
HHS Contribution:
Method of delivering radioactive compound to the target site while minimizing distribution of the compounds to other organs or tissues
Features:
The first radioimmunotherapy treatment approved for cancer
Inventors:
O. Gansow and M. Brechiel
HHS Institute/Agency:
NCI
Licensee:
Coulter Corporation  
Market Launch:
2002
2012
Product Name:
Zilver® PTX® Drug-Eluting Peripheral Stent
Use:
Used to prevent restenosis after balloon angioplasty of peripheral arteries
HHS Contribution:
Discovered that localized release of paclitaxel prevents artery narrowing from cell growth
Features:
First drug-eluting stent approved in the US to treat peripheral arterial disease
Inventors:
J. Kinsella, S. Sollott
HHS Institute/Agency:
NIA
Licensee:
Angiotech Pharmaceuticals / Cook Medical 
Market Launch:
2012