Technology Bundle ID: TAB-3346

Universal Influenza Virus Probes for Enrichment of Influenza Viral Sequences

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Primary Inventors: 
Yongli Xiao (NIAID)
Jeffery Taubenberger (NIAID), Zong-Mei Sheng (NIAID)
Development Stage: 
Pre-clinical (in vivo)
Institute or Center: 

This technology is a set of influenza virus enrichment probes developed to increase the sensitivity of sequence-based, universal detection of all influenza viruses. This universal influenza enrichment probe set contains a unique set of 46,953 biotin-labeled, RNA probes, each 120 base-pairs long, that can be used to enrich for any influenza sequences without prior knowledge of type or subtype. This probe set can capture and enrich influenza viral sequences selectively and effectively in a variety of samples, such as clinical samples with degraded nucleotides or samples containing very low amounts of influenza virus, thus making it a valuable tool for influenza virus diagnoses and surveillance.

This technology is available for licensing for commercial development in accordance with 35 U.S.C. § 209 and 37 CFR Part 404, as well as for further development and evaluation under a research collaboration.

  • Influenza diagnostics; influenza surveillance
  • Highly sensitive detection of influenza viruses
  • Detection of any influenza viruses in a variety of samples


PCT Application PCT/US2018/067713
Filed on 2018-12-27
US Application 62/611,734
Filed on 2017-12-29


Xiao Y, et al.
PMID 30212665


Jul 6, 2020

Data Source: